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Nutrients 2015, 7(5), 3621-3651; doi:10.3390/nu7053621

Selenium and Chronic Diseases: A Nutritional Genomics Perspective

1
School of Biomedical Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
2
Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
Received: 7 April 2015 / Revised: 28 April 2015 / Accepted: 6 May 2015 / Published: 15 May 2015
(This article belongs to the Special Issue Dietary Selenium and Human Health)
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Abstract

Mechanistic data have revealed a key role for selenium (Se) and selenoproteins in biological pathways known to be altered in multifactorial diseases, such as cellular maintenance, response to oxidative stress and correct protein folding. Although epidemiological studies indicate that low Se intake is linked to increased risk for various chronic diseases, supplementation trials have given confusing outcomes, suggesting that additional genetic factors could affect the relationship between Se and health. Genetic data support this hypothesis, as risk for several chronic diseases, in particular cancer, was linked to a number of single nucleotide polymorphisms (SNP) altering Se metabolism, selenoprotein synthesis or activity. Interactions between SNPs in selenoprotein genes, SNPs in related molecular pathways and biomarkers of Se status were found to further modulate the genetic risk carried by the SNPs. Taken together, nutritional genomics approaches uncovered the potential implication of some selenoproteins as well as the influence of complex interactions between genetic variants and Se status in the aetiology of several chronic diseases. This review discusses the results from these genetic associations in the context of selenoprotein functions and epidemiological investigations and emphasises the need to assess in future studies the combined contribution of Se status, environmental stress, and multiple or individual SNPs to disease risk. View Full-Text
Keywords: selenoprotein P; glutathione peroxidase; single nucleotide polymorphisms; cancer; nutritional genomics; selenium selenoprotein P; glutathione peroxidase; single nucleotide polymorphisms; cancer; nutritional genomics; selenium
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Méplan, C. Selenium and Chronic Diseases: A Nutritional Genomics Perspective. Nutrients 2015, 7, 3621-3651.

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