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Nutrients 2015, 7(5), 3067-3077; doi:10.3390/nu7053067

Maternal Consumption of Non-Staple Food in the First Trimester and Risk of Neural Tube Defects in Offspring

1
Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 WenhuaXilu Road, Jinan 250012, Shandong, China
2
Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, Zhejiang, China
*
Author to whom correspondence should be addressed.
Received: 12 February 2015 / Revised: 13 April 2015 / Accepted: 20 April 2015 / Published: 24 April 2015
(This article belongs to the Special Issue Nutrition in Pregnancy)
View Full-Text   |   Download PDF [139 KB, uploaded 24 April 2015]

Abstract

To study the associations between maternal consumption of non-staple food in the first trimester and risk of neural tube defects (NTDs) in offspring. Data collected from a hospital-based case-control study conducted between 2006 and 2008 in Shandong/Shanxi provinces including 459 mothers with NTDs-affected births and 459 mothers without NTDs-affected births. Logistic regression models were used to examine the associations between maternal consumption of non-staple food in the first trimester and risk of NTDs in offspring. The effects were evaluated by odds ratio (OR) and 95% confidence intervals (95% CIs) with SAS9.1.3.software. Maternal consumption of milk, fresh fruits and nuts in the first trimester were protective factors for total NTDs. Compared with consumption frequency of ˂1 meal/week, the ORs for milk consumption frequency of 1–2, 3–6, ≥7 meals/week were 0.50 (95% CI: 0.28–0.88), 0.56 (0.32–0.99), and 0.59 (0.38–0.90), respectively; the ORs for fresh fruits consumption frequency of 1–2, 3–6, ≥7 meals/week were 0.29 (95% CI: 0.12–0.72), 0.22 (0.09–0.53), and 0.32 (0.14–0.71), respectively; the ORs for nuts consumption frequency of 1–2, 3–6, ≥7 meals/week were 0.60 (95% CI: 0.38–0.94), 0.49 (0.31–0.79), and 0.63 (0.36–1.08), respectively. Different effects of above factors on NTDs were found for subtypes of anencephaly and spina bifida. Maternal non-staple food consumption of milk, fresh fruits and nuts in the first trimester was associated with reducing NTDs risk in offspring. View Full-Text
Keywords: case-control study; nutrition; neural tube defects case-control study; nutrition; neural tube defects
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, M.; Wang, Z.-P.; Gao, L.-J.; Yang, H.; Zhao, Z.-T. Maternal Consumption of Non-Staple Food in the First Trimester and Risk of Neural Tube Defects in Offspring. Nutrients 2015, 7, 3067-3077.

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