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Nutrients 2015, 7(3), 1871-1880; doi:10.3390/nu7031871

Live Longer with Vitamin D?

1
Academy for Micronutrient Medicine, Zweigertstr, 55, 45130 Essen, Germany
2
Department of Dermatology, The Saarland University Hospital, 66421 Homburg/Saar, Germany
3
Boston University Medical Center, 85 East Newton Street M-1013, Boston, MA 02118, USA
*
Author to whom correspondence should be addressed.
Received: 17 December 2014 / Revised: 25 February 2015 / Accepted: 3 March 2015 / Published: 12 March 2015
(This article belongs to the Special Issue Immune Regulation by Vitamin D)
View Full-Text   |   Download PDF [177 KB, uploaded 12 March 2015]   |  

Abstract

The global burden of vitamin D deficiency or insufficiency is of great concern for public health. According to recent studies, vitamin D deficiency is an important etiological factor in the pathogenesis of many chronic diseases. Whether or not there is a connection between 25-hydoxyvitamin D (25(OH)D) status and overall mortality is a matter of considerable debate. A new meta-analysis confirmed that low 25(OH)D levels were associated with a significant increased risk for all-cause mortality. Individuals with severe vitamin D deficiency have almost twice the mortality rate as those with 25(OH)D level ≥ 30 ng/mL, (≥75 nmol/L). Unlike previous meta-analyses which suggested that serum 25(OH)D > 50 ng/mL was associated with increased mortality, this new analysis found that there was no increased risk even when 25(OH)D levels were ≥70 ng/mL. In general, closer attention should be paid to vitamin D deficiency in medical and pharmaceutical practice than has been the case hitherto. The results of these studies are consistent with the recommendation to improve the general vitamin D status in children and adults by means of a healthy approach to sunlight exposure, consumption of foods containing vitamin D and supplementation with vitamin D preparations. View Full-Text
Keywords: vitamin D; 25-hydroxyvitamin D; vitamin D deficiency; breast cancer; cancer; overall mortality vitamin D; 25-hydroxyvitamin D; vitamin D deficiency; breast cancer; cancer; overall mortality
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gröber, U.; Reichrath, J.; Holick, M.F. Live Longer with Vitamin D? Nutrients 2015, 7, 1871-1880.

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