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Nutrients 2015, 7(2), 764-784; doi:10.3390/nu7020764

Intestinal Microbial Dysbiosis and Colonic Epithelial Cell Hyperproliferation by Dietary α-Mangostin is Independent of Mouse Strain

1
Human Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA
2
Food Innovation Center, The Ohio State University, Columbus, OH 43210, USA
3
Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
4
Division of Oral Biology, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA
5
Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
*
Author to whom correspondence should be addressed.
Received: 10 October 2014 / Revised: 14 January 2015 / Accepted: 15 January 2015 / Published: 22 January 2015
(This article belongs to the Special Issue Microbiome and Human Health)
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Abstract

Beverages and supplements prepared from mangosteen fruit are claimed to support gut health and immunity, despite the absence of supporting evidence from clinical trials. We recently reported that α-mangostin (α-MG), the most abundant xanthone in mangosteen fruit, altered the intestinal microbiome, promoted dysbiosis, and exacerbated colitis in C57BL/6J mice. The objective of this study was to determine whether induction of dysbiosis by dietary α-MG is limited to the C57BL/6J strain or represents a more generic response to chronic intake of the xanthone on the gut microbiota of mice. C3H, Balb/c, Nude FoxN1nu, and C57BL/6J mice, each demonstrating unique microbiomes, were fed standard diet or diet containing 0.1% α-MG for four weeks. Dietary α-MG significantly altered the cecal and colonic microbiota in all four strains of mice, promoting a reduction in generally assumed beneficial bacterial groups while increasing the abundance of pathogenic bacteria. Consumption of α-MG was associated with reduced abundance of Firmicutes and increased abundance of Proteobacteria. The abundance of Lachnospiraceae, Ruminococcaceae, and Lactobacillaceae was reduced in α-MG-fed mice, while that of Enterobacteriaceae and Enterococcaceae was increased. Dietary α-MG also was associated with increased proliferation of colonic epithelial cells, infiltration of immune cells, infiltration of immune cells and increased fluid content in stool. These results suggest that ingestion of pharmacologic doses of xanthones in mangosteen-containing supplements may adversely alter the gut microbiota and should be used with caution. View Full-Text
Keywords: mangosteen; alpha-mangostin; inflammation; gut microbiota; inflammatory bowel diseases; ulcerative colitis; colon mangosteen; alpha-mangostin; inflammation; gut microbiota; inflammatory bowel diseases; ulcerative colitis; colon
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gutierrez-Orozco, F.; Thomas-Ahner, J.M.; Galley, J.D.; Bailey, M.T.; Clinton, S.K.; Lesinski, G.B.; Failla, M.L. Intestinal Microbial Dysbiosis and Colonic Epithelial Cell Hyperproliferation by Dietary α-Mangostin is Independent of Mouse Strain. Nutrients 2015, 7, 764-784.

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