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Nutrients 2014, 6(9), 3818-3846; doi:10.3390/nu6093818

Does Vitamin C Deficiency Affect Cognitive Development and Function?

Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, DK-1870 Frederiksberg C, Copenhagen, Denmark
Author to whom correspondence should be addressed.
Received: 17 June 2014 / Revised: 14 August 2014 / Accepted: 1 September 2014 / Published: 19 September 2014
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Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(−/−) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies. View Full-Text
Keywords: vitamin C; cognition; oxidative stress; ROS; aging; development; stroke vitamin C; cognition; oxidative stress; ROS; aging; development; stroke

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Hansen, S.N.; Tveden-Nyborg, P.; Lykkesfeldt, J. Does Vitamin C Deficiency Affect Cognitive Development and Function? Nutrients 2014, 6, 3818-3846.

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