Vitamin E Concentrations in Adults with HIV/AIDS on Highly Active Antiretroviral Therapy
AbstractHIV/AIDS patients are probably more predisposed to vitamin E deficiency, considering that they are more exposed to oxidative stress. Additionally, there are an extensive number of drugs in the highly active antiretroviral therapy (HAART) regimens that may interfere with vitamin E concentrations. The objective of this study was to compare serum concentrations of alpha-tocopherol in 182 HIV/AIDS patients receiving different HAART regimens. The patients were divided into three groups according to regimen: nucleoside analog reverse-transcriptase inhibitors (NRTIs) + non-nucleoside analog reverse-transcriptase inhibitors (NNRTIs); NRTIs + protease inhibitors + ritonavir; NRTIs + other classes. Alpha-tocopherol was assessed by high-performance liquid chromatography. Multiple linear regression analysis was used to evaluate the effects of HAART regimen, time of use, and compliance with the regimen on alpha-tocopherol concentrations. Alpha-tocopherol concentrations were on average 4.12 μmol/L lower for the NRTIs + other classes regimen when compared to the NRTIs + NNRTIs regimen (p = 0.037). A positive association (p < 0.001) was observed between alpha-tocopherol and cholesterol concentrations, a finding due, in part, to the relationship between liposoluble vitamins and lipid profile. This study demonstrated differences in alpha-tocopherol concentrations between patients using different HAART regimens, especially regimens involving the use of new drugs. Long-term prospective cohort studies are needed to monitor vitamin E status in HIV/AIDS patients since the beginning of treatment. View Full-Text
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Kaio, D.J.I.; Rondó, P.H.C.; Luzia, L.A.; Souza, J.M.P.; Firmino, A.V.; Santos, S.S. Vitamin E Concentrations in Adults with HIV/AIDS on Highly Active Antiretroviral Therapy. Nutrients 2014, 6, 3641-3652.
Kaio DJI, Rondó PHC, Luzia LA, Souza JMP, Firmino AV, Santos SS. Vitamin E Concentrations in Adults with HIV/AIDS on Highly Active Antiretroviral Therapy. Nutrients. 2014; 6(9):3641-3652.Chicago/Turabian Style
Kaio, Daniella J.I.; Rondó, Patricia H.C.; Luzia, Liania A.; Souza, José M.P.; Firmino, Aline V.; Santos, Sigrid S. 2014. "Vitamin E Concentrations in Adults with HIV/AIDS on Highly Active Antiretroviral Therapy." Nutrients 6, no. 9: 3641-3652.