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Nutrients 2014, 6(7), 2668-2680; doi:10.3390/nu6072668

Chemopreventive Effects of Oplopantriol A, a Novel Compound Isolated from Oplopanax horridus, on Colorectal Cancer

1
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
2
Department of Anesthesia & Critical Care, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
3
Ben May Department for Cancer Research, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
4
Institute of Clinical Pharmacology, Central South University, Changsha 410000, China
5
State Key Laboratory of Quality Research in Chinese Medicine, and Institute of Chinese Medical Sciences, University of Macau, Macao, China
6
Committee on Clinical Pharmacology and Pharmacogenomics, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
*
Authors to whom correspondence should be addressed.
Received: 15 April 2014 / Revised: 12 June 2014 / Accepted: 1 July 2014 / Published: 18 July 2014
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Abstract

Oplopanax horridus is a North American botanical that has received limited investigations. We previously isolated over a dozen of the constituents from O. horridus, and among them oplopantriol A (OPT A) is a novel compound. In this study, we firstly evaluated the in vivo chemoprevention activities of OPT A using the xenograft colon cancer mouse model. Our data showed that this compound significantly suppressed tumor growth with dose-related effects (p < 0.01). Next, we characterized the compound’s growth inhibitory effects in human colorectal cancer cell lines HCT-116 and SW-480. With OPT A treatment, these malignant cells were significantly inhibited in both a concentration- and time-dependent manner (both p < 0.01). The IC50 was approximately 5 µM for HCT-116 and 7 µM for SW-480 cells. OPT A significantly induced apoptosis and arrested the cell cycle at the G2/M phase. From further mechanism explorations, our data showed that OPT A significantly upregulated the expression of a cluster of genes, especially the tumor necrosis factor receptor family and caspase family, suggesting that the tumor necrosis factor-related apoptotic pathway plays a key role in OPT A induced apoptosis. View Full-Text
Keywords: Oplopanax horridus; oplopantriol A; OPT A; chemoprevention; colorectal cancer; HCT-116; SW-480; apoptosis; cell cycle; tumor necrosis factors; death receptor signaling pathway Oplopanax horridus; oplopantriol A; OPT A; chemoprevention; colorectal cancer; HCT-116; SW-480; apoptosis; cell cycle; tumor necrosis factors; death receptor signaling pathway
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, Z.; Yu, C.; Zhang, C.-F.; Wu, X.-H.; Wen, X.-D.; Anderson, S.; Du, W.; Huang, W.-H.; Li, S.-P.; Wang, C.-Z.; Yuan, C.-S. Chemopreventive Effects of Oplopantriol A, a Novel Compound Isolated from Oplopanax horridus, on Colorectal Cancer. Nutrients 2014, 6, 2668-2680.

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