Chemopreventive Effects of Oplopantriol A, a Novel Compound Isolated from Oplopanax horridus, on Colorectal Cancer
AbstractOplopanax horridus is a North American botanical that has received limited investigations. We previously isolated over a dozen of the constituents from O. horridus, and among them oplopantriol A (OPT A) is a novel compound. In this study, we firstly evaluated the in vivo chemoprevention activities of OPT A using the xenograft colon cancer mouse model. Our data showed that this compound significantly suppressed tumor growth with dose-related effects (p < 0.01). Next, we characterized the compound’s growth inhibitory effects in human colorectal cancer cell lines HCT-116 and SW-480. With OPT A treatment, these malignant cells were significantly inhibited in both a concentration- and time-dependent manner (both p < 0.01). The IC50 was approximately 5 µM for HCT-116 and 7 µM for SW-480 cells. OPT A significantly induced apoptosis and arrested the cell cycle at the G2/M phase. From further mechanism explorations, our data showed that OPT A significantly upregulated the expression of a cluster of genes, especially the tumor necrosis factor receptor family and caspase family, suggesting that the tumor necrosis factor-related apoptotic pathway plays a key role in OPT A induced apoptosis. View Full-Text
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Zhang, Z.; Yu, C.; Zhang, C.-F.; Wu, X.-H.; Wen, X.-D.; Anderson, S.; Du, W.; Huang, W.-H.; Li, S.-P.; Wang, C.-Z.; Yuan, C.-S. Chemopreventive Effects of Oplopantriol A, a Novel Compound Isolated from Oplopanax horridus, on Colorectal Cancer. Nutrients 2014, 6, 2668-2680.
Zhang Z, Yu C, Zhang C-F, Wu X-H, Wen X-D, Anderson S, Du W, Huang W-H, Li S-P, Wang C-Z, Yuan C-S. Chemopreventive Effects of Oplopantriol A, a Novel Compound Isolated from Oplopanax horridus, on Colorectal Cancer. Nutrients. 2014; 6(7):2668-2680.Chicago/Turabian Style
Zhang, Zhiyu; Yu, Chunhao; Zhang, Chun-Feng; Wu, Xiao-Hui; Wen, Xiao-Dong; Anderson, Samantha; Du, Wei; Huang, Wei-Hua; Li, Shao-Ping; Wang, Chong-Zhi; Yuan, Chun-Su. 2014. "Chemopreventive Effects of Oplopantriol A, a Novel Compound Isolated from Oplopanax horridus, on Colorectal Cancer." Nutrients 6, no. 7: 2668-2680.