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Nutrients 2014, 6(6), 2436-2465; doi:10.3390/nu6062436

Interleukin-6 Gene Polymorphisms, Dietary Fat Intake, Obesity and Serum Lipid Concentrations in Black and White South African Women

1
UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town 7505, South Africa
2
Department of Statistics, University of Western Cape, Cape Town 7505, South Africa
3
Non-communicable Disease Research Unit (NCDRU), South African Medical Research Council, PO Box 19070, Tygerberg, Cape Town 7505, South Africa
*
Author to whom correspondence should be addressed.
Received: 6 March 2014 / Revised: 13 May 2014 / Accepted: 27 May 2014 / Published: 24 June 2014
(This article belongs to the Special Issue Nutrient: Gene Interactions)
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Abstract

This study investigated interactions between dietary fat intake and IL-6 polymorphisms on obesity and serum lipids in black and white South African (SA) women. Normal-weight and obese, black and white women underwent measurements of body composition, serum lipids and dietary fat intake, and were genotyped for the IL-6 −174 G>C, IVS3 +281 G>T and IVS4 +869 A>G polymorphisms. In black women the IVS4 +869 G allele was associated with greater adiposity, and with increasing dietary fat intake adiposity increased in the IVS3 +281 GT+GG and IVS4 +869 AA or AG genotypes. In white women, with increasing omega-3 (n-3) intake and decreasing n-6:n-3 ratio, body mass index (BMI) decreased in those with the −174 C allele, IVS3 +281 T allele and IVS4 +869 AG genotype. In the white women, those with the IVS3 +281 T allele had lower triglycerides. Further, with increasing n-3 polyunsaturated fatty acid (PUFA); triglyceride and total cholesterol:high-density lipoprotein cholesterol (T-C:HDL-C) ratio decreased in those with the −174 C allele. In black women, with increasing total fat intake, triglycerides and T-C:HDL-C ratio increased in those with the IVS4 +869 G allele. This study is the first to show that dietary fat intake modulates the relationship between the IL-6 −174 G>C, IVS3 +281 G>T and IVS4 +869 A>G polymorphisms on obesity and serum lipids in black and white SA women. View Full-Text
Keywords: IL-6 gene; dietary fat; obesity; serum lipids; ethnicity IL-6 gene; dietary fat; obesity; serum lipids; ethnicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Joffe, Y.T.; van der Merwe, L.; Evans, J.; Collins, M.; Lambert, E.V.; September, A.V.; Goedecke, J.H. Interleukin-6 Gene Polymorphisms, Dietary Fat Intake, Obesity and Serum Lipid Concentrations in Black and White South African Women. Nutrients 2014, 6, 2436-2465.

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