Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial
Abstract
:1. Introduction
2. Experimental Section
2.1. Test Material
Antioxidants | Level (per g) |
---|---|
Superoxide dismutase | 14,000 U |
Catalase | 1550 U |
Glutathione peroxydase | 155 U |
Co-enzyme Q10 | 0.08 mg |
Lipoic acid | 0.03 mg |
Glutathione | 0.33 μg |
Glutathione disulfide | 4.78 μg |
Carotenoids | 0.54 μg |
Vitamin A | 15.5 μg |
Vitamin E | 0.37 μg |
Vitamin C | 7.78 μg |
Selenium | 0.004 μg |
Total phenolics | 0.54 mg GAE 1 |
2.2. Methods: Psychometric Tools
2.3. Study Design
2.4. Statistical Analysis
3. Results
3.1. Study Population
Scores | Scores (Mean ± SEM) | Evolution between D0 and D84 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
D0 | D28 | D84 | P Group | S Group | |||||||
P Group | S Group | S vs. P p Value | P Group | S Group | S vs. P p Value | P Group | S Group | S vs. P p Value | p Value | p Value | |
PSS-14 | 42.5 ± 1.2 | 41.1 ± 1.0 | 0.3629 | 40.0 ± 1.1 | 36.5 ± 0.9 | <0.03 | 41.4 ± 0.9 | 38.4 ± 1.1 | <0.04 | >0.05 | <0.01 |
SF-36 | 43.6 ± 1.6 | 43.1 ± 1.5 | 0.8057 | 36.3 ± 1.9 | 35.3 ± 1.4 | >0.05 | 37.3 ± 2.5 | 34.9 ± 1.4 | <0.04 | <0.01 | <0.01 |
Stroop scale | 67.8 ± 2.7 | 73.2 ± 3.6 | 0.3586 | 80.1 ± 4.2 | 91.2 ± 5.0 | <0.04 | 77.5 ± 2.9 | 93.6 ± 4.8 | <0.001 | <0.05 | <0.01 |
Prevost scale | 95.7 ± 5.2 | 91.8 ± 3.3 | 0.7233 | 92.3 ± 4.7 | 84.7 ± 3.5 | >0.05 | 93.2 ± 4.8 | 84.4 ± 2.8 | <0.02 | >0.05 | <0.01 |
3.3. Quality of Life: SF 36® Health Survey
3.4. Stroop and Reverse Stroop Test
3.5. Prevost Subjective Fatigue Scale
4. Discussion
- -
- Perceived stress (Cohen scale PSS-14) and mental fatigue (Stroop score) at D28;
- -
- Perceived stress (Cohen scale PSS-14), physical fatigue (Prevost score), mental fatigue (Stroop score) and quality of life (SF 36) at D84.
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Carillon, J.; Notin, C.; Schmitt, K.; Simoneau, G.; Lacan, D. Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial. Nutrients 2014, 6, 2348-2359. https://doi.org/10.3390/nu6062348
Carillon J, Notin C, Schmitt K, Simoneau G, Lacan D. Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial. Nutrients. 2014; 6(6):2348-2359. https://doi.org/10.3390/nu6062348
Chicago/Turabian StyleCarillon, Julie, Claire Notin, Karine Schmitt, Guy Simoneau, and Dominique Lacan. 2014. "Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial" Nutrients 6, no. 6: 2348-2359. https://doi.org/10.3390/nu6062348