The Role of FADS1/2 Polymorphisms on Cardiometabolic Markers and Fatty Acid Profiles in Young Adults Consuming Fish Oil Supplements
Abstract
:1. Introduction
2. Methods
2.1. Participant Characteristics and Omega-3 Supplementation
2.2. Analysis of Cardiometabolic Markers
2.3. Fatty Acid Analysis
2.4. Analysis of Variants in the FADS1/2 Gene Cluster
2.5. Statistical Analysis
3. Results
3.1. Fish Oil Supplementation and Cardiometabolic Markers
Parameter | Baseline | Week 12 | Week 20 |
---|---|---|---|
BMI (kg/m2) | 25.7 ± 4.0 | ND | 25.8 ± 4.2 |
Triglyceride (mmol/L) | 0.9 ± 0.3 | 0.8 ± 0.3 * | 0.9 ± 0.5 |
Total cholesterol (mmol/L) | 4.0 ± 0.5 | 4.2 ± 0.7 | 4.0 ± 0.5 |
LDL-c (mmol/L) | 2.4 ± 0.5 | 2.5 ± 0.5 | 2.4 ± 0.4 |
HDL-c (mmol/L) | 1.3 ± 0.2 | 1.3 ± 0.3 | 1.3 ± 0.2 |
Cholesterol: HDL-c | 3.2 ± 0.6 | 3.3 ± 0.5 | 3.2 ± 0.5 |
Glucose (mmol/L) | 4.4 ± 1.4 | 3.9 ± 1.3 * | 4.2 ± 1.4 |
Insulin (ρmol/L) | 54.5 ± 22.1 | 46.8 ± 26.2 | 57.6 ± 28.5 |
HbA1c (mmol/L) | 0.05 ± 0.002 | 0.05 ± 0.002 | 0.05 ± 0.002 |
hsCRP (mg/L) | 1.4 ± 1.2 | 1.4 ± 1.3 | 1.2 ± 1.0 |
3.2. Fatty Acid Profiles in Serum and RBCs
3.3. Analysis of Variants in the FADS1/2 Gene Cluster
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Roke, K.; Mutch, D.M. The Role of FADS1/2 Polymorphisms on Cardiometabolic Markers and Fatty Acid Profiles in Young Adults Consuming Fish Oil Supplements. Nutrients 2014, 6, 2290-2304. https://doi.org/10.3390/nu6062290
Roke K, Mutch DM. The Role of FADS1/2 Polymorphisms on Cardiometabolic Markers and Fatty Acid Profiles in Young Adults Consuming Fish Oil Supplements. Nutrients. 2014; 6(6):2290-2304. https://doi.org/10.3390/nu6062290
Chicago/Turabian StyleRoke, Kaitlin, and David M. Mutch. 2014. "The Role of FADS1/2 Polymorphisms on Cardiometabolic Markers and Fatty Acid Profiles in Young Adults Consuming Fish Oil Supplements" Nutrients 6, no. 6: 2290-2304. https://doi.org/10.3390/nu6062290