Next Article in Journal
Phenolic Lipids Affect the Activity and Conformation of Acetylcholinesterase from Electrophorus electricus (Electric eel)
Previous Article in Journal
Pre-Exercise Nutrition: The Role of Macronutrients, Modified Starches and Supplements on Metabolism and Endurance Performance
Nutrients 2014, 6(5), 1809-1822; doi:10.3390/nu6051809
Article

Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression

,
,
 and *
Received: 18 March 2014; in revised form: 3 April 2014 / Accepted: 17 April 2014 / Published: 29 April 2014
View Full-Text   |   Download PDF [429 KB, uploaded 29 April 2014]   |   Browse Figures
Abstract: Vitamin C (VitC) has several roles in the brain acting both as a specific and non-specific antioxidant. The brain upholds a very high VitC concentration and is able to preferentially retain VitC even during deficiency. The accumulation of brain VitC levels much higher than in blood is primarily achieved by the sodium dependent VitC transporter (SVCT2). This study investigated the effects of chronic pre-and postnatal VitC deficiency as well as the effects of postnatal VitC repletion, on brain SVCT2 expression and markers of oxidative stress in young guinea pigs. Biochemical analyses demonstrated significantly decreased total VitC and an increased percentage of dehydroascorbic acid, as well as increased lipid oxidation (malondialdehyde), in the brains of VitC deficient animals (p < 0.0001) compared to controls. VitC repleted animals were not significantly different from controls. No significant changes were detected in either gene or protein expression of SVCT2 between groups or brain regions. In conclusion, chronic pre-and postnatal VitC deficiency increased brain redox imbalance but did not increase SVCT2 expression. Our findings show potential implications for VitC deficiency induced negative effects of redox imbalance in the brain and provide novel insight to the regulation of VitC in the brain during deficiency.
Keywords: vitamin C deficiency; SVCT2; redox imbalance; oxidative stress vitamin C deficiency; SVCT2; redox imbalance; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Paidi, M.D.; Schjoldager, J.G.; Lykkesfeldt, J.; Tveden-Nyborg, P. Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression. Nutrients 2014, 6, 1809-1822.

AMA Style

Paidi MD, Schjoldager JG, Lykkesfeldt J, Tveden-Nyborg P. Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression. Nutrients. 2014; 6(5):1809-1822.

Chicago/Turabian Style

Paidi, Maya D.; Schjoldager, Janne G.; Lykkesfeldt, Jens; Tveden-Nyborg, Pernille. 2014. "Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression." Nutrients 6, no. 5: 1809-1822.


Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert