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Acknowledgement to Reviewers of Nutrients in 2013
Nutrients 2014, 6(3), 931-949; doi:10.3390/nu6030931
Article

The Effect of Multivitamin/Mineral Supplements on Age-Related Cataracts: A Systematic Review and Meta-Analysis

1,* , 1
,
2
 and
1
1 Department of Ophthalmology, No. 181 Hospital of the PLA, No.1 Xinqiaoyuan Road, Guilin 541002, China 2 Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China
* Author to whom correspondence should be addressed.
Received: 30 November 2013 / Revised: 15 January 2014 / Accepted: 24 January 2014 / Published: 28 February 2014
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Abstract

Antioxidant vitamins supplements have been suggested as a strategy to decrease the risk of age-related cataract development. However, the results from observational studies and interventional trials of associations between antioxidant vitamins A, C, and E and cataract development have been inconsistent. We aim to evaluate the effectiveness of multivitamin/mineral supplements for decreasing the risk of age-related cataracts by conducting a systematic review and meta-analysis. In September 2013, we searched multiple databases to identify relevant studies including both cohort studies and randomized controlled trials (RCTs). A random-effects model was used to calculate the pooled relative risks (RR) with a 95% confidence interval (CI). Twelve prospective cohort studies and two RCTs were included. Pooled results from the cohort studies indicated that multivitamin/mineral supplements have a significant beneficial effect in decreasing the risk of nuclear cataracts (RR: 0.73; 95% CI: 0.64–0.82), cortical cataracts (RR: 0.81; 95% CI: 0.68–0.94), and any cataracts (RR: 0.66; 95% CI: 0.39–0.93). In addition, there were no decreases in the risk of posterior capsular cataracts (RR: 0.96; 95% CI: 0.72–1.20) or cataract surgery (RR: 1.00; 95% CI: 0.92–1.08). The two RCTs demonstrated that multivitamin/mineral supplements could decrease the risk of nuclear cataracts. There is sufficient evidence to support the role of dietary multivitamin/mineral supplements for the decreasing the risk of age-related cataracts.
Keywords: dietary supplements; cataract; vitamins; minerals; meta-analysis dietary supplements; cataract; vitamins; minerals; meta-analysis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Zhao, L.-Q.; Li, L.-M.; Zhu, H.; The Epidemiological Evidence-Based Eye Disease Study Research Group. The Effect of Multivitamin/Mineral Supplements on Age-Related Cataracts: A Systematic Review and Meta-Analysis. Nutrients 2014, 6, 931-949.

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