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Nutrients 2014, 6(2), 627-636; doi:10.3390/nu6020627
Short Communication

trans-11 18:1 Vaccenic Acid (TVA) Has a Direct Anti-Carcinogenic Effect on MCF-7 Human Mammary Adenocarcinoma Cells

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Received: 2 December 2013; in revised form: 18 December 2013 / Accepted: 23 January 2014 / Published: 10 February 2014
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Abstract: Trans vaccenic acid (TVA; trans-11 18:1) is a positional and geometric isomer of oleic acid and it is the predominant trans isomer found in ruminant fats. TVA can be converted into cis-9, trans-11 conjugated linoleic acid (c9, t11-CLA), a CLA isomer that has many beneficial effects, by stearoyl CoA desaturase 1 (SCD1) in the mammary gland. The health benefits associated with CLA are well documented, but it is unclear whether trans fatty acids (TFAs) from ruminant products have healthy effects. Therefore, the effects of TVA on the proliferation of MCF-7 human breast adenocarcinoma cells and MCF-10A human breast epithelial cells were investigated in the present study. Results showed that TVA inhibited the proliferation of MCF-7 cells but not MCF-10A cells by down-regulating the expression of Bcl-2 as well as procaspase-9. In addition, the suppressive effect of TVA was confirmed in SCD1-depleted MCF-7 cells. Our results suggested that TVA exerts a direct anti-carcinogenic effect on MCF-7 cells. These findings provided a better understanding of the research on the anti-carcinogenic effects of TVA and this may facilitate the manufacture of TVA/c9, t11-CLA fortified ruminant products.
Keywords: apoptotic protein; cancer cells; cis-9; trans-11conjugated linoleic acid; stearoyl CoA desaturase; trans fatty acids apoptotic protein; cancer cells; cis-9; trans-11conjugated linoleic acid; stearoyl CoA desaturase; trans fatty acids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lim, J.-N.; Oh, J.-J.; Wang, T.; Lee, J.-S.; Kim, S.-H.; Kim, Y.-J.; Lee, H.-G. trans-11 18:1 Vaccenic Acid (TVA) Has a Direct Anti-Carcinogenic Effect on MCF-7 Human Mammary Adenocarcinoma Cells. Nutrients 2014, 6, 627-636.

AMA Style

Lim J-N, Oh J-J, Wang T, Lee J-S, Kim S-H, Kim Y-J, Lee H-G. trans-11 18:1 Vaccenic Acid (TVA) Has a Direct Anti-Carcinogenic Effect on MCF-7 Human Mammary Adenocarcinoma Cells. Nutrients. 2014; 6(2):627-636.

Chicago/Turabian Style

Lim, Ji-Na; Oh, Jin-Ju; Wang, Tao; Lee, Jae-Sung; Kim, Sang-Hun; Kim, Yoon-Jin; Lee, Hong-Gu. 2014. "trans-11 18:1 Vaccenic Acid (TVA) Has a Direct Anti-Carcinogenic Effect on MCF-7 Human Mammary Adenocarcinoma Cells." Nutrients 6, no. 2: 627-636.



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