Nutrients 2014, 6(2), 504-516; doi:10.3390/nu6020504
Article

Alcohol Consumption and Risk of Glioma: A Meta-Analysis of 19 Observational Studies

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Received: 25 October 2013; in revised form: 24 December 2013 / Accepted: 9 January 2014 / Published: 27 January 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The relationship between risk of glioma and alcohol consumption has been widely studied, but results have been conflicting. We therefore conducted a meta-analysis of observational studies to systematically assess the relationship between alcohol drinking and risk of glioma. Two electronic databases (PubMed and EMBASE) were searched from inception to 8 August 2013 to identify pertinent studies that linked alcohol drinking with glioma risk. We used a random-effects model to calculate the overall relative risk (RR) with corresponding 95% confidence intervals (CIs). Fifteen case-control and four cohort studies were identified for this analysis. The combined RR for total alcohol drinkers versus non-drinkers was 0.96 (95% CI: 0.89–1.04). In the subgroup analysis by geographic area, a significant association was observed in North American studies (RR = 0.78, 95% CI: 0.65–0.93), but not in European or Asian/Australian studies. In the subgroup analysis by study design, a borderline significant association emerged in population-based case-control studies (RR = 0.82, 95% CI: 0.68–0.99), but not in hospital-based case-control studies (RR = 1.00, 95% CI: 0.99–1.01) or cohort group (RR = 1.03, 95% CI: 0.88–1.20). Our results show no material association between alcohol consumption and risk of glioma existed. Further prospective evidences are needed to confirm this association.
Keywords: glioma; alcohol drinking; ethanol; meta-analysis; risk factor
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MDPI and ACS Style

Qi, Z.-Y.; Shao, C.; Yang, C.; Wang, Z.; Hui, G.-Z. Alcohol Consumption and Risk of Glioma: A Meta-Analysis of 19 Observational Studies. Nutrients 2014, 6, 504-516.

AMA Style

Qi Z-Y, Shao C, Yang C, Wang Z, Hui G-Z. Alcohol Consumption and Risk of Glioma: A Meta-Analysis of 19 Observational Studies. Nutrients. 2014; 6(2):504-516.

Chicago/Turabian Style

Qi, Zhen-Yu; Shao, Chuan; Yang, Chao; Wang, Zhong; Hui, Guo-Zhen. 2014. "Alcohol Consumption and Risk of Glioma: A Meta-Analysis of 19 Observational Studies." Nutrients 6, no. 2: 504-516.

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