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Nutrients 2014, 6(2), 504-516; doi:10.3390/nu6020504
Article

Alcohol Consumption and Risk of Glioma: A Meta-Analysis of 19 Observational Studies

,
* ,
,
 and
Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
* Author to whom correspondence should be addressed.
Received: 25 October 2013 / Revised: 24 December 2013 / Accepted: 9 January 2014 / Published: 27 January 2014
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Abstract

The relationship between risk of glioma and alcohol consumption has been widely studied, but results have been conflicting. We therefore conducted a meta-analysis of observational studies to systematically assess the relationship between alcohol drinking and risk of glioma. Two electronic databases (PubMed and EMBASE) were searched from inception to 8 August 2013 to identify pertinent studies that linked alcohol drinking with glioma risk. We used a random-effects model to calculate the overall relative risk (RR) with corresponding 95% confidence intervals (CIs). Fifteen case-control and four cohort studies were identified for this analysis. The combined RR for total alcohol drinkers versus non-drinkers was 0.96 (95% CI: 0.89–1.04). In the subgroup analysis by geographic area, a significant association was observed in North American studies (RR = 0.78, 95% CI: 0.65–0.93), but not in European or Asian/Australian studies. In the subgroup analysis by study design, a borderline significant association emerged in population-based case-control studies (RR = 0.82, 95% CI: 0.68–0.99), but not in hospital-based case-control studies (RR = 1.00, 95% CI: 0.99–1.01) or cohort group (RR = 1.03, 95% CI: 0.88–1.20). Our results show no material association between alcohol consumption and risk of glioma existed. Further prospective evidences are needed to confirm this association.
Keywords: glioma; alcohol drinking; ethanol; meta-analysis; risk factor glioma; alcohol drinking; ethanol; meta-analysis; risk factor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Qi, Z.-Y.; Shao, C.; Yang, C.; Wang, Z.; Hui, G.-Z. Alcohol Consumption and Risk of Glioma: A Meta-Analysis of 19 Observational Studies. Nutrients 2014, 6, 504-516.

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