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Nutrients 2014, 6(10), 4404-4420; doi:10.3390/nu6104404

Resveratrol Based Oral Nutritional Supplement Produces Long-Term Beneficial Effects on Structure and Visual Function in Human Patients

1
Eye Clinic 112e, Captain James A Lovell Federal Health Care Center, 3001 Green Bay Rd., North Chicago, IL 60064, USA
2
University of Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, IL 60612, USA
3
Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Rd., North Chicago, IL 60064, USA
*
Author to whom correspondence should be addressed.
Received: 25 June 2014 / Revised: 25 August 2014 / Accepted: 16 September 2014 / Published: 17 October 2014
(This article belongs to the Special Issue Nutritional Epigenetics)
View Full-Text   |   Download PDF [1571 KB, uploaded 17 October 2014]   |  

Abstract

Background: Longevinex® (L/RV) is a low dose hormetic over-the-counter (OTC) oral resveratrol (RV) based matrix of red wine solids, vitamin D3 and inositol hexaphosphate (IP6) with established bioavailability, safety, and short-term efficacy against the earliest signs of human atherosclerosis, murine cardiac reperfusion injury, clinical retinal neovascularization, and stem cell survival. We previously reported our short-term findings for dry and wet age-related macular degeneration (AMD) patients. Today we report long term (two to three year) clinical efficacy. Methods: We treated three patients including a patient with an AMD treatment resistant variant (polypoidal retinal vasculature disease). We evaluated two clinical measures of ocular structure (fundus autofluorescent imaging and spectral domain optical coherence extended depth choroidal imaging) and qualitatively appraised changes in macular pigment volume. We further evaluated three clinical measures of visual function (Snellen visual acuity, contrast sensitivity, and glare recovery to a cone photo-stress stimulus). Results: We observed broad bilateral improvements in ocular structure and function over a long time period, opposite to what might be expected due to aging and the natural progression of the patient’s pathophysiology. No side effects were observed. Conclusions: These three cases demonstrate that application of epigenetics has long-term efficacy against AMD retinal disease, when the retinal specialist has exhausted other therapeutic modalities. View Full-Text
Keywords: epigenetics; visual structure and function; resveratrol; Longevinex®; age-related macular degeneration; ophthalmology epigenetics; visual structure and function; resveratrol; Longevinex®; age-related macular degeneration; ophthalmology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Richer, S.; Patel, S.; Sockanathan, S.; Ulanski, L.J., II; Miller, L.; Podella, C. Resveratrol Based Oral Nutritional Supplement Produces Long-Term Beneficial Effects on Structure and Visual Function in Human Patients. Nutrients 2014, 6, 4404-4420.

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