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Association between Lutein and Zeaxanthin Status and the Risk of Cataract: A Meta-Analysis
The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, 277 Yanta West Road, Xi'an 710061, China
School of Public Health, Xi'an Jiaotong University College of Medicine, 76 Yanta West Road, Xi'an 710061, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 11 November 2013; in revised form: 14 January 2014 / Accepted: 15 January 2014 / Published: 22 January 2014
Abstract: The purpose of this meta-analysis was to evaluate the relationship between blood lutein and zeaxanthin concentration and the risk of age-related cataract (ARC). MEDLINE, EMBASE, ISI and Cochrane Library were searched to identify relevant studies up to April 2013. Meta-analysis was conducted to obtain pooled relative risks (RRs) for the highest-versus-lowest categories of blood lutein and zeaxanthin concentrations. One cohort study and seven cross-sectional studies were included in the meta-analysis. There were significant inverse associations between nuclear cataract and blood lutein and zeaxanthin concentrations, with the pooled RRs ranging from 0.63 (95% confidence interval (CI): 0.49, 0.77) for zeaxanthin to 0.73 (95% CI: 0.59, 0.87) for lutein. A stronger association between nuclear cataract and blood zeaxanthin might be noted for the studies conducted in the European Nations. Blood lutein and zeaxanthin were also noted to lead towards a decrease in the risk of cortical cataract and subcapsular cataract; however, these pooled RRs were not statistically significant, with the exception of a marginal association between lutein and subcapsular cataract. Our results suggest that high blood lutein and zeaxanthin are significantly associated with a decrease in the risk of nuclear cataract. However, no significant associations were found for ARC in other regions of the lens.
Keywords: lutein; zeaxanthin; blood; age-related cataract; meta-analysis
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Liu, X.-H.; Yu, R.-B.; Liu, R.; Hao, Z.-X.; Han, C.-C.; Zhu, Z.-H.; Ma, L. Association between Lutein and Zeaxanthin Status and the Risk of Cataract: A Meta-Analysis. Nutrients 2014, 6, 452-465.
Liu X-H, Yu R-B, Liu R, Hao Z-X, Han C-C, Zhu Z-H, Ma L. Association between Lutein and Zeaxanthin Status and the Risk of Cataract: A Meta-Analysis. Nutrients. 2014; 6(1):452-465.
Liu, Xiao-Hong; Yu, Rong-Bin; Liu, Rong; Hao, Zhen-Xuan; Han, Cheng-Cheng; Zhu, Zhong-Hai; Ma, Le. 2014. "Association between Lutein and Zeaxanthin Status and the Risk of Cataract: A Meta-Analysis." Nutrients 6, no. 1: 452-465.