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Nutrients 2014, 6(1), 452-465; doi:10.3390/nu6010452
Article

Association between Lutein and Zeaxanthin Status and the Risk of Cataract: A Meta-Analysis

1,†
,
2,†
,
2,†
,
2
,
2
,
2
 and
2,*
1 The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, 277 Yanta West Road, Xi'an 710061, China 2 School of Public Health, Xi'an Jiaotong University College of Medicine, 76 Yanta West Road, Xi'an 710061, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 11 November 2013 / Revised: 14 January 2014 / Accepted: 15 January 2014 / Published: 22 January 2014
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Abstract

The purpose of this meta-analysis was to evaluate the relationship between blood lutein and zeaxanthin concentration and the risk of age-related cataract (ARC). MEDLINE, EMBASE, ISI and Cochrane Library were searched to identify relevant studies up to April 2013. Meta-analysis was conducted to obtain pooled relative risks (RRs) for the highest-versus-lowest categories of blood lutein and zeaxanthin concentrations. One cohort study and seven cross-sectional studies were included in the meta-analysis. There were significant inverse associations between nuclear cataract and blood lutein and zeaxanthin concentrations, with the pooled RRs ranging from 0.63 (95% confidence interval (CI): 0.49, 0.77) for zeaxanthin to 0.73 (95% CI: 0.59, 0.87) for lutein. A stronger association between nuclear cataract and blood zeaxanthin might be noted for the studies conducted in the European Nations. Blood lutein and zeaxanthin were also noted to lead towards a decrease in the risk of cortical cataract and subcapsular cataract; however, these pooled RRs were not statistically significant, with the exception of a marginal association between lutein and subcapsular cataract. Our results suggest that high blood lutein and zeaxanthin are significantly associated with a decrease in the risk of nuclear cataract. However, no significant associations were found for ARC in other regions of the lens.
Keywords: lutein; zeaxanthin; blood; age-related cataract; meta-analysis lutein; zeaxanthin; blood; age-related cataract; meta-analysis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Liu, X.-H.; Yu, R.-B.; Liu, R.; Hao, Z.-X.; Han, C.-C.; Zhu, Z.-H.; Ma, L. Association between Lutein and Zeaxanthin Status and the Risk of Cataract: A Meta-Analysis. Nutrients 2014, 6, 452-465.

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