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Nutrients 2014, 6(1), 190-206; doi:10.3390/nu6010190
Article

Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia: A Randomized Controlled Trial

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Received: 21 October 2013; in revised form: 11 November 2013 / Accepted: 14 November 2013 / Published: 31 December 2013
(This article belongs to the Special Issue Vitamin A and Carotenoids)
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Abstract: Iron deficiency anaemia (IDA) is the most common nutritional deficiency in the world including developed and developing countries. Despite intensive efforts to improve the quality of life of rural and aboriginal communities in Malaysia, anaemia and IDA are still major public health problems in these communities particularly among children. A randomized, double-blind, placebo-controlled trial was conducted on 250 Orang Asli (aboriginal) schoolchildren in Malaysia to investigate the effects of a single high-dose of vitamin A supplementation (200,000 IU) on iron status indices, anaemia and IDA status. The effect of the supplement was assessed after 3 months of receiving the supplements; after a complete 3-day deworming course of 400 mg/day of albendazole tablets. The prevalence of anaemia was found to be high: 48.5% (95% CI = 42.3, 54.8). Moreover, 34% (95% CI = 28.3, 40.2) of the children had IDA, which accounted for 70.1% of the anaemic cases. The findings showed that the reduction in serum ferritin level and the increments in haemoglobin, serum iron and transferrin saturation were found to be significant among children allocated to the vitamin A group compared to those allocated to the placebo group (p < 0.01). Moreover, a significant reduction in the prevalence of IDA by almost 22% than prevalence at baseline was reported among children in the vitamin A group compared with only 2.3% reduction among children in the placebo group. In conclusion, vitamin A supplementation showed a significant impact on iron status indices and IDA among Orang Asli children. Hence, providing vitamin A supplementation and imparting the knowledge related to nutritious food should be considered in the efforts to improve the nutritional and health status of these children as a part of efforts to improve the quality of life in rural and aboriginal communities.
Keywords: clinical trial; vitamin A supplementation; iron deficiency anaemia; children; Malaysia clinical trial; vitamin A supplementation; iron deficiency anaemia; children; Malaysia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Al-Mekhlafi, H.M.; Al-Zabedi, E.M.; Al-Maktari, M.T.; Atroosh, W.M.; Al-Delaimy, A.K.; Moktar, N.; Sallam, A.A.; Abdullah, W.A.; Jani, R.; Surin, J. Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia: A Randomized Controlled Trial. Nutrients 2014, 6, 190-206.

AMA Style

Al-Mekhlafi HM, Al-Zabedi EM, Al-Maktari MT, Atroosh WM, Al-Delaimy AK, Moktar N, Sallam AA, Abdullah WA, Jani R, Surin J. Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia: A Randomized Controlled Trial. Nutrients. 2014; 6(1):190-206.

Chicago/Turabian Style

Al-Mekhlafi, Hesham M.; Al-Zabedi, Ebtesam M.; Al-Maktari, Mohamed T.; Atroosh, Wahib M.; Al-Delaimy, Ahmed K.; Moktar, Norhayati; Sallam, Atiya A.; Abdullah, Wan A.; Jani, Rohana; Surin, Johari. 2014. "Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia: A Randomized Controlled Trial." Nutrients 6, no. 1: 190-206.


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