Nutrients 2013, 5(6), 2222-2230; doi:10.3390/nu5062222
Article

Iron in Child Obesity. Relationships with Inflammation and Metabolic Risk Factors

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Received: 21 March 2013; in revised form: 27 May 2013 / Accepted: 2 June 2013 / Published: 19 June 2013
(This article belongs to the Special Issue Dietary Iron and Human Health)
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Abstract: Iron (Fe) sequestration is described in overweight and in its associated metabolic complications, i.e., metabolic syndrome (MetS) and non-alcoholic liver fatty disease (NAFLD); however, the interactions between Fe, obesity and inflammation make it difficult to recognize the specific role of each of them in the risk of obesity-induced metabolic diseases. Even the usual surrogate marker of Fe stores, ferritin, is influenced by inflammation; therefore, in obese subjects inflammation parameters must be measured together with those of Fe metabolism. This cross-sectional study in obese youth (502 patients; 57% girls): 11.4 ± 3.0 years old (x ± SD); BMI z score 5.5 ± 2.3), multivariate regression analysis showed associations between Fe storage assessed by serum ferritin with risk factors for MetS and NAFLD, assessed by transaminase levels, which were independent of overweight and the acute phase protein fibrinogen. Further studies incorporating the measurement of complementary parameters of Fe metabolism could improve the comprehension of mechanisms involved.
Keywords: iron; obesity; children; inflammation; metabolic syndrome; non alcoholic fatty liver disease (NAFLD)
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MDPI and ACS Style

Bouglé, D.; Brouard, J. Iron in Child Obesity. Relationships with Inflammation and Metabolic Risk Factors. Nutrients 2013, 5, 2222-2230.

AMA Style

Bouglé D, Brouard J. Iron in Child Obesity. Relationships with Inflammation and Metabolic Risk Factors. Nutrients. 2013; 5(6):2222-2230.

Chicago/Turabian Style

Bouglé, Dominique; Brouard, Jacques. 2013. "Iron in Child Obesity. Relationships with Inflammation and Metabolic Risk Factors." Nutrients 5, no. 6: 2222-2230.


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