Nutrients 2013, 5(6), 2206-2221; doi:10.3390/nu5062206
Review

The Role of Vitamin D in Hematologic Disease and Stem Cell Transplantation

Division of Hematology and Medical Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
* Author to whom correspondence should be addressed.
Received: 9 May 2013; in revised form: 3 June 2013 / Accepted: 8 June 2013 / Published: 18 June 2013
(This article belongs to the Special Issue Vitamin D and Human Health)
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Abstract: Vitamin D is a steroid hormone with a broad range of biological effects ranging from the classical role as a mediator of calcium and phosphate balance to cellular differentiation and immune modulation. These effects impact normal and dysfunctional hematopoietic and immune function, which may allow an avenue for improved treatment and support of patients suffering from hematologic disorders. In this review, we will summarize the role of vitamin D in normal hematopoiesis, discuss ways in which vitamin D may improve outcomes, and discuss a potential role of vitamin D for treating hematologic disorders and modulating the immune system to improve the outcome of allogeneic stem cell transplant.
Keywords: vitamin D; differentiation therapy; acute leukemia; allogeneic stem cell transplant

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MDPI and ACS Style

Hall, A.C.; Juckett, M.B. The Role of Vitamin D in Hematologic Disease and Stem Cell Transplantation. Nutrients 2013, 5, 2206-2221.

AMA Style

Hall AC, Juckett MB. The Role of Vitamin D in Hematologic Disease and Stem Cell Transplantation. Nutrients. 2013; 5(6):2206-2221.

Chicago/Turabian Style

Hall, Aric C.; Juckett, Mark B. 2013. "The Role of Vitamin D in Hematologic Disease and Stem Cell Transplantation." Nutrients 5, no. 6: 2206-2221.

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