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The Role of Vitamin D in Hematologic Disease and Stem Cell Transplantation
Division of Hematology and Medical Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
* Author to whom correspondence should be addressed.
Received: 9 May 2013; in revised form: 3 June 2013 / Accepted: 8 June 2013 / Published: 18 June 2013
Abstract: Vitamin D is a steroid hormone with a broad range of biological effects ranging from the classical role as a mediator of calcium and phosphate balance to cellular differentiation and immune modulation. These effects impact normal and dysfunctional hematopoietic and immune function, which may allow an avenue for improved treatment and support of patients suffering from hematologic disorders. In this review, we will summarize the role of vitamin D in normal hematopoiesis, discuss ways in which vitamin D may improve outcomes, and discuss a potential role of vitamin D for treating hematologic disorders and modulating the immune system to improve the outcome of allogeneic stem cell transplant.
Keywords: vitamin D; differentiation therapy; acute leukemia; allogeneic stem cell transplant
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Cite This Article
MDPI and ACS Style
Hall, A.C.; Juckett, M.B. The Role of Vitamin D in Hematologic Disease and Stem Cell Transplantation. Nutrients 2013, 5, 2206-2221.
Hall AC, Juckett MB. The Role of Vitamin D in Hematologic Disease and Stem Cell Transplantation. Nutrients. 2013; 5(6):2206-2221.
Hall, Aric C.; Juckett, Mark B. 2013. "The Role of Vitamin D in Hematologic Disease and Stem Cell Transplantation." Nutrients 5, no. 6: 2206-2221.