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Nutrients 2013, 5(4), 1287-1300; doi:10.3390/nu5041287
Review

Functionality of Fatty Acid Chemoreception: A Potential Factor in the Development of Obesity?

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Received: 21 January 2013; in revised form: 26 February 2013 / Accepted: 4 April 2013 / Published: 17 April 2013
(This article belongs to the Special Issue Nutrition and Cardiovascular Diseases)
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Abstract: Excess dietary fat consumption is recognized as a strong contributing factor in the development of overweight and obesity. Understanding why some individuals are better than others at regulating fat intake will become increasingly important and emerging associative evidence implicates attenuated fatty acid sensing in both the oral cavity and gastrointestinal (GI) tract in the development of obesity. Functional implications of impaired fatty acid chemoreception include diminished activation of the gustatory system, the cephalic response and satiety. This review will focus on knowledge from animal and human studies supporting the existence of oral fatty acid chemoreception including putative oral detection mechanisms, and how sensitivity to fatty acids is associated with fat consumption and fatty food preference.
Keywords: oral fatty acid chemoreception; oral sensitivity; fat regulation; obesity; BMI; CD36; GPCRs oral fatty acid chemoreception; oral sensitivity; fat regulation; obesity; BMI; CD36; GPCRs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Newman, L.; Haryono, R.; Keast, R. Functionality of Fatty Acid Chemoreception: A Potential Factor in the Development of Obesity? Nutrients 2013, 5, 1287-1300.

AMA Style

Newman L, Haryono R, Keast R. Functionality of Fatty Acid Chemoreception: A Potential Factor in the Development of Obesity? Nutrients. 2013; 5(4):1287-1300.

Chicago/Turabian Style

Newman, Lisa; Haryono, Rivkeh; Keast, Russell. 2013. "Functionality of Fatty Acid Chemoreception: A Potential Factor in the Development of Obesity?" Nutrients 5, no. 4: 1287-1300.


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