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Nutrients 2013, 5(4), 1253-1275; https://doi.org/10.3390/nu5041253

Higher Serum 25-Hydroxyvitamin D Concentrations Associate with a Faster Recovery of Skeletal Muscle Strength after Muscular Injury

1
The Orthopedic Specialty Hospital, Murray, UT 84107, USA
2
ARUP Laboratories, Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA
3
Department of Pathology, Pediatrics and Medicine, University of Utah, Salt Lake City, UT 84132, USA
4
USANA Health Sciences, Inc., Salt Lake City, UT 84120, USA
5
Hyperbaric Medicine, Intermountain Medical Center, Murray, UT 84107, USA
6
LDS Hospital, Salt Lake City, UT 84143, USA
7
School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
*
Author to whom correspondence should be addressed.
Received: 30 January 2013 / Revised: 18 March 2013 / Accepted: 29 March 2013 / Published: 17 April 2013
(This article belongs to the Special Issue Vitamin D and Human Health)
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Abstract

The primary purpose of this study was to identify if serum 25-hydroxyvitamin D (25(OH)D) concentrations predict muscular weakness after intense exercise. We hypothesized that pre-exercise serum 25(OH)D concentrations inversely predict exercise-induced muscular weakness. Fourteen recreationally active adults participated in this study. Each subject had one leg randomly assigned as a control. The other leg performed an intense exercise protocol. Single-leg peak isometric force and blood 25(OH)D, aspartate and alanine aminotransferases, albumin, interferon (IFN)-γ, and interleukin-4 were measured prior to and following intense exercise. Following exercise, serum 25(OH)D concentrations increased (p < 0.05) immediately, but within minutes, subsequently decreased (p < 0.05). Circulating albumin increases predicted (p < 0.005) serum 25(OH)D increases, while IFN-γ increases predicted (p < 0.001) serum 25(OH)D decreases. Muscular weakness persisted within the exercise leg (p < 0.05) and compared to the control leg (p < 0.05) after the exercise protocol. Serum 25(OH)D concentrations inversely predicted (p < 0.05) muscular weakness (i.e., control leg vs. exercise leg peak isometric force) immediately and days (i.e., 48-h and 72-h) after exercise, suggesting the attenuation of exercise-induced muscular weakness with increasing serum 25(OH)D prior to exercise. Based on these data, we conclude that pre-exercise serum 25(OH)D concentrations could influence the recovery of skeletal muscle strength after an acute bout of intense exercise. View Full-Text
Keywords: vitamin D; exercise; muscle strength; cytokines; albumin vitamin D; exercise; muscle strength; cytokines; albumin
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Barker, T.; Henriksen, V.T.; Martins, T.B.; Hill, H.R.; Kjeldsberg, C.R.; Schneider, E.D.; Dixon, B.M.; Weaver, L.K. Higher Serum 25-Hydroxyvitamin D Concentrations Associate with a Faster Recovery of Skeletal Muscle Strength after Muscular Injury. Nutrients 2013, 5, 1253-1275.

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