Nutrients 2013, 5(4), 1253-1275; doi:10.3390/nu5041253
Article

Higher Serum 25-Hydroxyvitamin D Concentrations Associate with a Faster Recovery of Skeletal Muscle Strength after Muscular Injury

1 The Orthopedic Specialty Hospital, Murray, UT 84107, USA 2 ARUP Laboratories, Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA 3 Department of Pathology, Pediatrics and Medicine, University of Utah, Salt Lake City, UT 84132, USA 4 USANA Health Sciences, Inc., Salt Lake City, UT 84120, USA 5 Hyperbaric Medicine, Intermountain Medical Center, Murray, UT 84107, USA 6 LDS Hospital, Salt Lake City, UT 84143, USA 7 School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
* Author to whom correspondence should be addressed.
Received: 30 January 2013; in revised form: 18 March 2013 / Accepted: 29 March 2013 / Published: 17 April 2013
(This article belongs to the Special Issue Vitamin D and Human Health)
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Abstract: The primary purpose of this study was to identify if serum 25-hydroxyvitamin D (25(OH)D) concentrations predict muscular weakness after intense exercise. We hypothesized that pre-exercise serum 25(OH)D concentrations inversely predict exercise-induced muscular weakness. Fourteen recreationally active adults participated in this study. Each subject had one leg randomly assigned as a control. The other leg performed an intense exercise protocol. Single-leg peak isometric force and blood 25(OH)D, aspartate and alanine aminotransferases, albumin, interferon (IFN)-γ, and interleukin-4 were measured prior to and following intense exercise. Following exercise, serum 25(OH)D concentrations increased (p < 0.05) immediately, but within minutes, subsequently decreased (p < 0.05). Circulating albumin increases predicted (p < 0.005) serum 25(OH)D increases, while IFN-γ increases predicted (p < 0.001) serum 25(OH)D decreases. Muscular weakness persisted within the exercise leg (p < 0.05) and compared to the control leg (p < 0.05) after the exercise protocol. Serum 25(OH)D concentrations inversely predicted (p < 0.05) muscular weakness (i.e., control leg vs. exercise leg peak isometric force) immediately and days (i.e., 48-h and 72-h) after exercise, suggesting the attenuation of exercise-induced muscular weakness with increasing serum 25(OH)D prior to exercise. Based on these data, we conclude that pre-exercise serum 25(OH)D concentrations could influence the recovery of skeletal muscle strength after an acute bout of intense exercise.
Keywords: vitamin D; exercise; muscle strength; cytokines; albumin

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MDPI and ACS Style

Barker, T.; Henriksen, V.T.; Martins, T.B.; Hill, H.R.; Kjeldsberg, C.R.; Schneider, E.D.; Dixon, B.M.; Weaver, L.K. Higher Serum 25-Hydroxyvitamin D Concentrations Associate with a Faster Recovery of Skeletal Muscle Strength after Muscular Injury. Nutrients 2013, 5, 1253-1275.

AMA Style

Barker T, Henriksen VT, Martins TB, Hill HR, Kjeldsberg CR, Schneider ED, Dixon BM, Weaver LK. Higher Serum 25-Hydroxyvitamin D Concentrations Associate with a Faster Recovery of Skeletal Muscle Strength after Muscular Injury. Nutrients. 2013; 5(4):1253-1275.

Chicago/Turabian Style

Barker, Tyler; Henriksen, Vanessa T.; Martins, Thomas B.; Hill, Harry R.; Kjeldsberg, Carl R.; Schneider, Erik D.; Dixon, Brian M.; Weaver, Lindell K. 2013. "Higher Serum 25-Hydroxyvitamin D Concentrations Associate with a Faster Recovery of Skeletal Muscle Strength after Muscular Injury." Nutrients 5, no. 4: 1253-1275.

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