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Soluble Fiber Dextrin and Soluble Corn Fiber Supplementation Modify Indices of Health in Cecum and Colon of Sprague-Dawley Rats
Department of Animal Sciences, University of Illinois, 1207 W. Gregory Drive, Urbana, IL 61801, USA
Department of Food Science and Human Nutrition, University of Illinois, 905 S. Goodwin Avenue, Urbana, IL 61801, USA
* Author to whom correspondence should be addressed.
Received: 28 November 2012; in revised form: 18 January 2013 / Accepted: 21 January 2013 / Published: 4 February 2013
Abstract: The objective of this study was to evaluate health outcomes resulting from dietary supplementation of novel, low-digestible carbohydrates in the cecum and colon of Sprague-Dawley rats randomly assigned to one of four treatment groups for 21 days: 5% cellulose (Control), Pectin, soluble fiber dextrin (SFD), or soluble corn fiber (SCF). Rats fed Pectin had a higher average daily food intake, but no differences in final body weights or rates of weight gain among treatments were observed. No differences were observed in total short-chain fatty acid (SCFA) or branched-chain fatty acid (BCFA) concentrations in the cecum and colon of rats fed either SFD or SCF. The SFD and SCF treatments increased cecal propionate and decreased butyrate concentrations compared to Control or Pectin. Pectin resulted in increased BCFA in the cecum and colon. Supplementation of SFD and SCF had no effect on cecal microbial populations compared to Control. Consumption of SFD and SCF increased total and empty cecal weight but not colon weight. Gut histomorphology was positively affected by SFD and SCF. Increased crypt depth, goblet cell numbers, and acidic mucin were observed in both the cecum and colon of rats supplemented with SFD, SCF, and Pectin. These novel, low-digestible carbohydrates appear to be beneficial in modulating indices of hindgut morphology when supplemented in the diet of the rat.
Keywords: cecal fermentation; histomorphology; soluble fiber dextrin; soluble corn fiber
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Knapp, B.K.; Bauer, L.L.; Swanson, K.S.; Tappenden, K.A.; Fahey, G.C., Jr.; de Godoy, M.R.C. Soluble Fiber Dextrin and Soluble Corn Fiber Supplementation Modify Indices of Health in Cecum and Colon of Sprague-Dawley Rats. Nutrients 2013, 5, 396-410.
Knapp BK, Bauer LL, Swanson KS, Tappenden KA, Fahey GC, Jr, de Godoy MRC. Soluble Fiber Dextrin and Soluble Corn Fiber Supplementation Modify Indices of Health in Cecum and Colon of Sprague-Dawley Rats. Nutrients. 2013; 5(2):396-410.
Knapp, Brenda K.; Bauer, Laura L.; Swanson, Kelly S.; Tappenden, Kelly A.; Fahey, George C., Jr.; de Godoy, Maria R.C. 2013. "Soluble Fiber Dextrin and Soluble Corn Fiber Supplementation Modify Indices of Health in Cecum and Colon of Sprague-Dawley Rats." Nutrients 5, no. 2: 396-410.