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Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast Cancer
Department of Family Medicine, Stony Brook University Hospital Medical Center, Stony Brook, New York, NY 11794, USA
Received: 25 September 2012; in revised form: 30 November 2012 / Accepted: 24 January 2013 / Published: 31 January 2013
Abstract: While many factors are involved in the etiology of cancer, it has been clearly established that diet significantly impacts one’s risk for this disease. More recently, specific food components have been identified which are uniquely beneficial in mitigating the risk of specific cancer subtypes. Plant sterols are well known for their effects on blood cholesterol levels, however research into their potential role in mitigating cancer risk remains in its infancy. As outlined in this review, the cholesterol modulating actions of plant sterols may overlap with their anti-cancer actions. Breast cancer is the most common malignancy affecting women and there remains a need for effective adjuvant therapies for this disease, for which plant sterols may play a distinctive role.
Keywords: plant sterols; cholesterol; cancer; breast cancer; beta-sitosterol; AMPK; bisphosphonates; statins
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Cite This Article
MDPI and ACS Style
Grattan, B.J. Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast Cancer. Nutrients 2013, 5, 359-387.
Grattan BJ. Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast Cancer. Nutrients. 2013; 5(2):359-387.
Grattan, Bruce J. 2013. "Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast Cancer." Nutrients 5, no. 2: 359-387.