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Nutrients 2013, 5(12), 4894-4907; doi:10.3390/nu5124894
Article

Phenolic Composition, Antioxidant Activity and Anti-Adipogenic Effect of Hot Water Extract from Safflower (Carthamus tinctorius L.) Seed

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1 Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea 2 Department of Animal Resources Technology, Gyeongnam National University of Science and Technology, Jinju 660-758, Korea 3 Department of Food and Biotechnology, Hoseo University, Asan 336-795, Korea 4 Department of Food Science and Technology, Kongju National University, Yesan 340-800, Korea 5 Korea Food Research Institute, Gyeonggi 463-746, Korea
* Author to whom correspondence should be addressed.
Received: 19 June 2013 / Revised: 12 November 2013 / Accepted: 20 November 2013 / Published: 28 November 2013
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Abstract

This study was to evaluate the phenolic content and composition of Carthamus tinctorius L. seed extract (CSE) and to further assess its antioxidant and anti-adipogenic activities using various radical scavenging systems and 3T3-L1 cells. Our results show that the total phenolic and flavonoid contents of CSE were 126.0 ± 2.4 mg GAE/g and 62.2 ± 1.9 mg QE/g, respectively. The major phenolic compounds in CSE was (−)-epigallocatechin (109.62 mg/g), with a 4-hydroxy benzhydrazide derivative and gallocatechin present at 18.28 mg/g and 17.02 mg/g, respectively. CSE exhibited remarkable radical scavenging activities, FRAP (ferric reducing antioxidant power) and reducing power in a dose-dependent manner. Moreover, the oxygen radical absorbance capacity (ORAC) value of CSE (0.1 mg/mL) was 62.9 ± 4.7 μM TE (trolox equivalent)/g. During adipogenesis, CSE significantly inhibited fat accumulation in 3T3-L1 cells compared with control cells. Overall, these results indicate that CSE might be a valuable source of bioactive compounds that impart functional food and natural antioxidant properties.
Keywords: antioxidant activity; phenolic compound; Carthamus tinctorius L. seed; 3T3-L1 adipocyte; hot-water extract antioxidant activity; phenolic compound; Carthamus tinctorius L. seed; 3T3-L1 adipocyte; hot-water extract
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Yu, S.-Y.; Lee, Y.-J.; Kim, J.-D.; Kang, S.-N.; Lee, S.-K.; Jang, J.-Y.; Lee, H.-K.; Lim, J.-H.; Lee, O.-H. Phenolic Composition, Antioxidant Activity and Anti-Adipogenic Effect of Hot Water Extract from Safflower (Carthamus tinctorius L.) Seed. Nutrients 2013, 5, 4894-4907.

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