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Nutrients 2012, 4(9), 1304-1316; doi:10.3390/nu4091304
Article

Hypocholesterolemic Effects of Lactic Acid-Fermented Soymilk on Rats Fed a High Cholesterol Diet

1
, 2
, 3
 and 1,*
Received: 16 July 2012; in revised form: 31 August 2012 / Accepted: 5 September 2012 / Published: 18 September 2012
(This article belongs to the Special Issue Dietary Lipids: Sources, Function and Metabolism)
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Abstract: The effect of fermented soymilk on rats fed a high cholesterol diet was investigated to clarify the cholesterol-lowering function. Male Sprague-Dawley rats aged 7 weeks were fed a control diet (1% cholesterol, high cholesterol diet), high cholesterol diet containing 11.7% fermented soymilk diet (5% soy protein as final concentration, F-5), or high cholesterol diet containing 23.4% fermented soymilk diet (10% soy protein as final concentration, F-10) for 5 weeks. The liver weight and fat mass were decreased by the ingestion of fermented soymilk. The hepatic triglyceride and cholesterol levels in the F-5 and F-10 groups were significantly lowered compared to those in the control group. The plasma total cholesterol level of the F-10 group was significantly decreased. The expression of SREBP-2, a cholesterol synthesis-related gene, was significantly decreased in liver of the F-5 group, but the expression of CYP7a1, a cholesterol catabolism-related gene, was significantly increased. These results suggest that fermented soymilk can modulate the cholesterol metabolism in rats fed a high cholesterol diet.
Keywords: fermented soymilk; cholesterol; lipid metabolism fermented soymilk; cholesterol; lipid metabolism
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kobayashi, M.; Hirahata, R.; Egusa, S.; Fukuda, M. Hypocholesterolemic Effects of Lactic Acid-Fermented Soymilk on Rats Fed a High Cholesterol Diet. Nutrients 2012, 4, 1304-1316.

AMA Style

Kobayashi M, Hirahata R, Egusa S, Fukuda M. Hypocholesterolemic Effects of Lactic Acid-Fermented Soymilk on Rats Fed a High Cholesterol Diet. Nutrients. 2012; 4(9):1304-1316.

Chicago/Turabian Style

Kobayashi, Maki; Hirahata, Rie; Egusa, Shintaro; Fukuda, Mitsuru. 2012. "Hypocholesterolemic Effects of Lactic Acid-Fermented Soymilk on Rats Fed a High Cholesterol Diet." Nutrients 4, no. 9: 1304-1316.


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