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Nutrients 2011, 3(11), 929-936; doi:10.3390/nu3110929

Differential Mammary Gland Development in FVB and C57Bl/6 Mice: Implications for Breast Cancer Research

Department of Human Health & Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada
* Author to whom correspondence should be addressed.
Received: 3 August 2011 / Revised: 5 October 2011 / Accepted: 11 October 2011 / Published: 25 October 2011
(This article belongs to the Special Issue Diet and Cancer Prevention)
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A growing body of research suggests a linkage between pubertal mammary gland development and environmental factors such as diet as modifiers of long term breast cancer risk. Much of this research is dependent upon mouse models, which may vary between studies. However, effects may be strain dependent and further modified by diet, which has not been previously examined. Therefore, the objective of the present study was to determine whether mammary gland development differs between FVB and C57Bl/6 strains on diets containing either n-6 or n-3 polyunsaturated fats. Developmental measures related to onset of puberty and mammary gland development differed between strains. Mice fed the n-3 polyunsaturated fatty acids (PUFA) diet were shown to have lower numbers of terminal end buds, a marker of mammary gland development. This study helps to further clarify differences in development and dietary response between FVB and C57Bl/6 mice in order to more appropriately relate mammary gland research to human populations.
Keywords: mammary gland; terminal end buds (TEB); FVB; C57Bl/6; breast cancer mammary gland; terminal end buds (TEB); FVB; C57Bl/6; breast cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MacLennan, M.B.; Anderson, B.M.; Ma, D.W. Differential Mammary Gland Development in FVB and C57Bl/6 Mice: Implications for Breast Cancer Research. Nutrients 2011, 3, 929-936.

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