Next Article in Journal / Special Issue
Caffeinated Coffee, Decaffeinated Coffee and Endometrial Cancer Risk: A Prospective Cohort Study among US Postmenopausal Women
Previous Article in Journal
Apical Localization of Zinc Transporter ZnT4 in Human Airway Epithelial Cells and Its Loss in a Murine Model of Allergic Airway Inflammation
Previous Article in Special Issue
Induction of Cancer Cell Death by Isoflavone: The Role of Multiple Signaling Pathways
Article Menu

Export Article

Open AccessArticle
Nutrients 2011, 3(11), 929-936; doi:10.3390/nu3110929

Differential Mammary Gland Development in FVB and C57Bl/6 Mice: Implications for Breast Cancer Research

Department of Human Health & Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada
Author to whom correspondence should be addressed.
Received: 3 August 2011 / Revised: 5 October 2011 / Accepted: 11 October 2011 / Published: 25 October 2011
(This article belongs to the Special Issue Diet and Cancer Prevention)
View Full-Text   |   Download PDF [421 KB, uploaded 25 October 2011]   |  


A growing body of research suggests a linkage between pubertal mammary gland development and environmental factors such as diet as modifiers of long term breast cancer risk. Much of this research is dependent upon mouse models, which may vary between studies. However, effects may be strain dependent and further modified by diet, which has not been previously examined. Therefore, the objective of the present study was to determine whether mammary gland development differs between FVB and C57Bl/6 strains on diets containing either n-6 or n-3 polyunsaturated fats. Developmental measures related to onset of puberty and mammary gland development differed between strains. Mice fed the n-3 polyunsaturated fatty acids (PUFA) diet were shown to have lower numbers of terminal end buds, a marker of mammary gland development. This study helps to further clarify differences in development and dietary response between FVB and C57Bl/6 mice in order to more appropriately relate mammary gland research to human populations. View Full-Text
Keywords: mammary gland; terminal end buds (TEB); FVB; C57Bl/6; breast cancer mammary gland; terminal end buds (TEB); FVB; C57Bl/6; breast cancer

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

MacLennan, M.B.; Anderson, B.M.; Ma, D.W. Differential Mammary Gland Development in FVB and C57Bl/6 Mice: Implications for Breast Cancer Research. Nutrients 2011, 3, 929-936.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top