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Differential Mammary Gland Development in FVB and C57Bl/6 Mice: Implications for Breast Cancer Research
Department of Human Health & Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada
* Author to whom correspondence should be addressed.
Received: 3 August 2011; in revised form: 5 October 2011 / Accepted: 11 October 2011 / Published: 25 October 2011
Abstract: A growing body of research suggests a linkage between pubertal mammary gland development and environmental factors such as diet as modifiers of long term breast cancer risk. Much of this research is dependent upon mouse models, which may vary between studies. However, effects may be strain dependent and further modified by diet, which has not been previously examined. Therefore, the objective of the present study was to determine whether mammary gland development differs between FVB and C57Bl/6 strains on diets containing either n-6 or n-3 polyunsaturated fats. Developmental measures related to onset of puberty and mammary gland development differed between strains. Mice fed the n-3 polyunsaturated fatty acids (PUFA) diet were shown to have lower numbers of terminal end buds, a marker of mammary gland development. This study helps to further clarify differences in development and dietary response between FVB and C57Bl/6 mice in order to more appropriately relate mammary gland research to human populations.
Keywords: mammary gland; terminal end buds (TEB); FVB; C57Bl/6; breast cancer
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MDPI and ACS Style
MacLennan, M.B.; Anderson, B.M.; Ma, D.W. Differential Mammary Gland Development in FVB and C57Bl/6 Mice: Implications for Breast Cancer Research. Nutrients 2011, 3, 929-936.
MacLennan MB, Anderson BM, Ma DW. Differential Mammary Gland Development in FVB and C57Bl/6 Mice: Implications for Breast Cancer Research. Nutrients. 2011; 3(11):929-936.
MacLennan, Mira B.; Anderson, Breanne M.; Ma, David W.L. 2011. "Differential Mammary Gland Development in FVB and C57Bl/6 Mice: Implications for Breast Cancer Research." Nutrients 3, no. 11: 929-936.