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Nutrients 2010, 2(8), 889-902; doi:10.3390/nu2080889
Review

Flavonoids: Antioxidants Against Atherosclerosis

1,2,* , 1
 and 1
Received: 12 July 2010; in revised form: 2 August 2010 / Accepted: 6 August 2010 / Published: 12 August 2010
(This article belongs to the Special Issue Dietary Antioxidants)
View Full-Text   |   Download PDF [654 KB, uploaded 12 August 2010]
Abstract: Oxidative stress results from an imbalance between excessive formation of reactive oxygen species (ROS) and/or reactive nitrogen species and limited antioxidant defences. Endothelium and nitric oxide (NO) are key regulators of vascular health. NO bioavailability is modulated by ROS that degrade NO, uncouple NO synthase, and inhibit synthesis. Cardiovascular risk conditions contribute to oxidative stress, causing an imbalance between NO and ROS, with a relative decrease in NO bioavailability. Dietary flavonoids represent a range of polyphenolic compounds naturally occurring in plant foods. Flavonoids are potentially involved in cardiovascular prevention mainly by decreasing oxidative stress and increasing NO bioavailability.
Keywords: oxidative stress; endothelial dysfunction; atherosclerosis; antioxidants; flavonoids oxidative stress; endothelial dysfunction; atherosclerosis; antioxidants; flavonoids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Grassi, D.; Desideri, G.; Ferri, C. Flavonoids: Antioxidants Against Atherosclerosis. Nutrients 2010, 2, 889-902.

AMA Style

Grassi D, Desideri G, Ferri C. Flavonoids: Antioxidants Against Atherosclerosis. Nutrients. 2010; 2(8):889-902.

Chicago/Turabian Style

Grassi, Davide; Desideri, Giovambattista; Ferri, Claudio. 2010. "Flavonoids: Antioxidants Against Atherosclerosis." Nutrients 2, no. 8: 889-902.


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