Abstract: Acne vulgaris may be improved by dietary factors that increase insulin sensitivity. We hypothesized that a low-glycemic index diet would improve facial acne severity and insulin sensitivity. Fifty-eight adolescent males (mean age ± standard deviation 16.5 ± 1.0 y and body mass index 23.1 ± 3.5 kg/m2) were alternately allocated to high or low glycemic index diets. Severity of inflammatory lesions on the face, insulin sensitivity (homeostasis modeling assessment of insulin resistance), androgens and insulin-like growth factor-1 and its binding proteins were assessed at baseline and at eight weeks, a period corresponding to the school term. Forty-three subjects (n = 23 low glycemic index and n = 20 high glycemic index) completed the study. Diets differed significantly in glycemic index (mean ± standard error of the mean, low glycemic index 51 ± 1 vs. high glycemic index 61 ± 2, p = 0.0002), but not in macronutrient distribution or fiber content. Facial acne improved on both diets (low glycemic index −26 ± 6%, p = 0.0004 and high glycemic index −16 ± 7%, p = 0.01), but differences between diets did not reach significance. Change in insulin sensitivity was not different between diets (low glycemic index 0.2 ± 0.1 and high glycemic index 0.1 ± 0.1, p = 0.60) and did not correlate with change in acne severity (Pearson correlation r = −0.196, p = 0.244). Longer time frames, greater reductions in glycemic load or/and weight loss may be necessary to detect improvements in acne among adolescent boys.
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Reynolds, R.C.; Lee, S.; Choi, J.Y.J.; Atkinson, F.S.; Stockmann, K.S.; Petocz, P.; Brand-Miller, J.C. Effect of the Glycemic Index of Carbohydrates on Acne vulgaris. Nutrients 2010, 2, 1060-1072.
Reynolds RC, Lee S, Choi JYJ, Atkinson FS, Stockmann KS, Petocz P, Brand-Miller JC. Effect of the Glycemic Index of Carbohydrates on Acne vulgaris. Nutrients. 2010; 2(10):1060-1072.
Reynolds, Rebecca C.; Lee, Stephen; Choi, James Y. J.; Atkinson, Fiona S.; Stockmann, Karola S.; Petocz, Peter; Brand-Miller, Jennie C. 2010. "Effect of the Glycemic Index of Carbohydrates on Acne vulgaris." Nutrients 2, no. 10: 1060-1072.