Next Article in Journal
Regiospecific Profiles of Fatty Acids in Triacylglycerols and Phospholipids from Adzuki Beans (Vigna angularis)
Next Article in Special Issue
Assessment of Information to Substantiate a Health Claim on the Prevention of Prostate Cancer by Lignans
Previous Article in Journal
The Gluten-Free Diet: Safety and Nutritional Quality
Nutrients 2010, 2(1), 35-48; doi:10.3390/nu2010035

Epidemiologic Studies of Isoflavones & Mammographic Density

1,* , 1
1 Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA 2 Department of Medicine, University of California, San Francisco, 1701 Divisadero Street, San Francisco, CA 94143, USA
* Author to whom correspondence should be addressed.
Received: 12 November 2009 / Accepted: 15 January 2010 / Published: 19 January 2010
(This article belongs to the Special Issue Isoflavones and Lignans)
View Full-Text   |   Download PDF [207 KB, uploaded 19 January 2010]   |   Browse Figure


Isoflavones, phytoestrogens in soy beans with estrogen-like properties, have been examined for their cancer protective effects. Mammographic density is a strong predictor of breast cancer. This review summarizes studies that have examined the association between isoflavones and breast density. Observational investigations in Hawaii and Singapore suggest slightly lower breast density among women of Asian descent with regular soy intake, but two larger studies from Japan and Singapore did not observe a protective effect. The findings from seven randomized trials with primarily Caucasian women indicate that soy or isoflavones do not modify mammographic density. Soy foods and isoflavone supplements within a nutritional range do not appear to modify breast cancer risk as assessed by mammographic density.
Keywords: breast cancer risk; mammographic density; soy foods; isoflavones; Asian ethnicity; epidemiology; randomized trials breast cancer risk; mammographic density; soy foods; isoflavones; Asian ethnicity; epidemiology; randomized trials
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Maskarinec, G.; Verheus, M.; A. Tice, J. Epidemiologic Studies of Isoflavones & Mammographic Density. Nutrients 2010, 2, 35-48.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert