Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals and Treatment
2.2. Fasting Glucose and Insulin Measurements
2.3. Nrf2 Activity Assay
2.4. In Vivo Bioluminescence Measurements
2.5. Immunohistochemistry
2.6. Real-Time PCR
2.7. Statistical Analysis
3. Results
3.1. Partial Nrf2 Ablation in Nrf2+/− Mice and Its Impact on Nrf2 Activity
3.2. Metabolic Parameters in Nrf2+/− Mice and the Effects of HFD
3.3. Impact of Partial Nrf2 Ablation on Senescence Induction in Various Tissues
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Balasubramanian, P.; Kiss, T.; Gulej, R.; Nyul Toth, A.; Tarantini, S.; Yabluchanskiy, A.; Ungvari, Z.; Csiszar, A. Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence. Nutrients 2024, 16, 952. https://doi.org/10.3390/nu16070952
Balasubramanian P, Kiss T, Gulej R, Nyul Toth A, Tarantini S, Yabluchanskiy A, Ungvari Z, Csiszar A. Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence. Nutrients. 2024; 16(7):952. https://doi.org/10.3390/nu16070952
Chicago/Turabian StyleBalasubramanian, Priya, Tamas Kiss, Rafal Gulej, Adam Nyul Toth, Stefano Tarantini, Andriy Yabluchanskiy, Zoltan Ungvari, and Anna Csiszar. 2024. "Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence" Nutrients 16, no. 7: 952. https://doi.org/10.3390/nu16070952