Next Article in Journal
A Scoping Review of the Operationalization of Fruit and Vegetable Variety
Next Article in Special Issue
B Vitamins and Their Role in Immune Regulation and Cancer
Previous Article in Journal
Nutrients, Diet, and Other Factors in Prenatal Life and Bone Health in Young Adults: A Systematic Review of Longitudinal Studies
Previous Article in Special Issue
Vitamin B6, Inflammation, and Cardiovascular Outcome in a Population-Based Cohort: The Prevention of Renal and Vascular End-Stage Disease (PREVEND) Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 12
Issue 9
10.3390/nu12092867
Review Report
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease

Nutrients 2020, 12(9), 2867; https://doi.org/10.3390/nu12092867
by Peter Lyon 1,2, Victoria Strippoli 1,2, Byron Fang 1,2 and Luisa Cimmino 1,2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Nutrients 2020, 12(9), 2867; https://doi.org/10.3390/nu12092867
Submission received: 31 August 2020 / Revised: 17 September 2020 / Accepted: 17 September 2020 / Published: 19 September 2020
(This article belongs to the Special Issue Water-Soluble Vitamins in Development, Blood Cell Maintenance and Cancer)

Round 1

Reviewer 1 Report

The review manuscript by Lyon et al reviewed the role of micronutrients (folate, B12 and methionine) in one-carbon metabolism in normal and pathological conditions. The authors provide a very good review of different components of one-carbon metabolism, consequences arising from their deficiencies or excess, and targeting one-carbon metabolism for treating different neurological and hematological diseases as well as cancer. The manuscript is very well written with proper illustrations, and therefore, easy to understand. The content of the manuscript is well within the scope of this journal, and it can be very interesting to researchers working in these fields of research.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

ID: Nutrients-934497

The manuscript is well structured, and concepts are well described and detailed.

Items are properly presented and discussed.

I have only comments on the paragraph 2.4 and 3.1:

Paragraph 2.4

Although the work is mainly focused on one-carbon metabolism by B vitamins, the author should describe the pathway catalised by MUT in Detail, inserting it in Figure 1.

Line 131-132: appropriate literature should be cited for example:

  • DOI:3390/ijms21144998
  • DOI:3390/ijms19113580

Paragraph 3.1

Line 168-169: Authors should describe the Problems of newborn Screening, when propionic acidemia and methylmalonic acidemia is included, how sensitiv or insensitiv newborn screening for the disorders of cobalamin metabolism is.

Also an appropriate literature should be cited, for example:

  • DOI:1016/j.clinbiochem.2014.08.020

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 3 Report

Interesting review on vitamin B. Perhaps the only issue I think it has not been clearly discussed is the use of demethylating agents in colon cancer and its relation to vitamin B uptake. In general, easy to read and well documented review

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Back to TopTop