Next Article in Journal
Association between Dietary Inflammatory Index, C-Reactive Protein and Metabolic Syndrome: A Cross-Sectional Study
Previous Article in Journal
Obesity with Comorbid Eating Disorders: Associated Health Risks and Treatment Approaches
Article Menu

Export Article

Open AccessArticle
Nutrients 2018, 10(7), 830; https://doi.org/10.3390/nu10070830

Antiobesity Effects of Ginsenoside Rg1 on 3T3-L1 Preadipocytes and High Fat Diet-Induced Obese Mice Mediated by AMPK

1
College of Life Science, Jilin Agricultural University, Changchun, Jilin 130118, China
2
National Engineering Laboratory for Wheat and Corn Deep Processing, Changchun, Jilin 130118, China
3
College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China
4
Chinese Medicine Science Academy of Jilin Province, Changchun, Jilin 130118, China
*
Author to whom correspondence should be addressed.
Received: 16 May 2018 / Revised: 7 June 2018 / Accepted: 21 June 2018 / Published: 27 June 2018
View Full-Text   |   Download PDF [13840 KB, uploaded 27 June 2018]   |  

Abstract

Ginsenosides Rg1 is one of the major pharmacologically active saponins in ginseng, which as an antioxidant reduces oxidative damage in the liver and can also be used to prevent cardiovascular diseases and diabetes. However, there is no research targeting the effect of lipid metabolism in high-fat diet (HFD)-induced mice. In this study, we evaluated the anti-obesity effects of Rg1 in 3T3-L1 adipocyte cells and HFD-induced obese C57BL/6J mice. Administration of Rg1 to HFD-induced obese mice significantly decreased body weight, total cholesterol, and total triglyceride levels. In addition to effects in 3T3-L1 cells, Rg1 reduced the accumulation of lipid droplets in a dose-dependent manner. Furthermore, Rg1 exhibits an anti-adipogenic effect via regulation of the expression of the transcriptional factors and lipid metabolism-related genes in vivo and in vitro. We observed that Rg1 administration significantly increased the phosphorylation level of AMP-activated protein kinase (AMPK) in both epididymal white adipose tissue and 3T3-L1 cells. These results indicated that Rg1 works both in an anti-adipogenic and anti-obesity manner through inducing AMPK activation, inhibiting lipogenesis, and decreasing intracellular lipid content, adipocyte size, and adipose weight. View Full-Text
Keywords: ginsenoside Rg1; obesity; adipogenesis; lipogenesis; lipolysis; AMPK ginsenoside Rg1; obesity; adipogenesis; lipogenesis; lipolysis; AMPK
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Liu, H.; Wang, J.; Liu, M.; Zhao, H.; Yaqoob, S.; Zheng, M.; Cai, D.; Liu, J. Antiobesity Effects of Ginsenoside Rg1 on 3T3-L1 Preadipocytes and High Fat Diet-Induced Obese Mice Mediated by AMPK. Nutrients 2018, 10, 830.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top