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Nutrients 2018, 10(6), 724; https://doi.org/10.3390/nu10060724

Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer

1
Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Gyeonggi-do, Korea
2
Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Goyang 10408, Gyeonggi-do, Korea
3
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 03080, Korea
*
Author to whom correspondence should be addressed.
Received: 2 May 2018 / Revised: 22 May 2018 / Accepted: 31 May 2018 / Published: 5 June 2018
Full-Text   |   PDF [241 KB, uploaded 5 June 2018]

Abstract

A proinflammatory diet may increase the risk of colorectal cancer, but its role may differ according to individuals’ genetic variants. We aimed to examine whether a specific dietary pattern reflecting inflammation was associated with a risk of colorectal cancer and whether IL-17F genetic variant altered this association. In a study of 695 colorectal cancer cases and 1846 controls, we derived a reduced rank regression dietary pattern using 32 food groups as predictors and the plasma C-reactive protein (CRP) concentration as the response. High CRP levels were associated with a high risk of colorectal cancer (OR (95% CI) = 3.58 (2.65–4.82) for the highest quartile vs. lowest quartile). After adjusting for potential confounding factors, high pattern scores were associated with a high risk of colorectal cancer (OR (95% CI) = 9.98 (6.81–14.62) for the highest quartile vs. lowest quartile). When stratified by the IL-17F rs763780 genotype, this association was stronger for individuals carrying the C allele (p for interaction = 0.034), particularly for individuals with rectal cancer (p for interaction = 0.011). In conclusion, a dietary pattern reflecting inflammation was significantly associated with colorectal cancer risk. Moreover, this association could be modified according to the IL-17F rs763780 genotype and anatomic site. View Full-Text
Keywords: colorectal cancer; inflammation; C-reactive protein; dietary pattern; IL-17F polymorphism colorectal cancer; inflammation; C-reactive protein; dietary pattern; IL-17F polymorphism
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cho, Y.A.; Lee, J.; Oh, J.H.; Chang, H.J.; Sohn, D.K.; Shin, A.; Kim, J. Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer. Nutrients 2018, 10, 724.

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