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Nutrients 2018, 10(6), 690; https://doi.org/10.3390/nu10060690

Effects on Fatty Acid Metabolism of a New Powdered Human Milk Fortifier Containing Medium-Chain Triacylglycerols and Docosahexaenoic Acid in Preterm Infants

1
CIC Pédiatrique 1401 CHU, 33000 Bordeaux, France
2
ITERG, Université de Bordeaux, 33076 Bordeaux, France
3
Nestlé Health Sciences, 1066 Epalinges, Switzerland
4
Nestlé Research Centre, 1000 Lausanne, Switzerland
5
Nestlé Nutrition R&D, 1800 Vevey, Switzerland
6
Department of Neonatology, University of Liège, 4000 Liège, Belgium
7
Hôpital de la Croix Rousse, Hospices Civils, 69004 Lyon, France
8
Hôpital Clocheville, CHU de Tours, 37004 Tours, France
*
Author to whom correspondence should be addressed.
Received: 27 February 2018 / Revised: 17 May 2018 / Accepted: 25 May 2018 / Published: 29 May 2018
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Abstract

Preterm infants require fortification of human milk (HM) with essential fatty acids (FA) to ensure adequate post-natal development. As part of a larger randomized controlled study, we investigated FA metabolism in a subset of 47 clinically stable preterm infants (birth weight ≤1500 g or gestational age ≤32 weeks). Infants were randomized to receive HM supplemented with either a new HM fortifier (nHMF; n = 26) containing 12.5 g medium-chain FA (MCFA), 958 mg linoleic acid (LA), 417 mg α-linolenic acid (ALA), and 157 mg docosahexaenoic acid (DHA) per 100 g of powder (in compliance with the latest guidelines) or a fat-free HMF (cHMF; n = 21). Plasma phospholipid (PL) and triacylglycerol (TAG), and red blood cell phosphatidylcholine (RBC-PC) and phosphatidylethanolamine (RBC-PE) FA profiles were assessed before and after 21 days of feeding. In the nHMF group, significantly increased levels of n-9 monounsaturated fatty acids were observed, formed most likely by elongation and desaturation of dietary saturated fatty acids present in HM. ALA fortification increased ALA assimilation into plasma TAG. Similarly, DHA fortification enriched the DHA content in RBC-PE, which, in this compartment, was not associated with lower arachidonic acid levels as observed in plasma TAG and phospholipids. RBC-PE, a reliable indicator of FA metabolism and accretion, was the most sensitive compartment in this study. View Full-Text
Keywords: arachidonic acid; docosahexaenoic acid; fatty acid metabolism; medium-chain fatty acids; preterm infants arachidonic acid; docosahexaenoic acid; fatty acid metabolism; medium-chain fatty acids; preterm infants
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Billeaud, C.; Boué-Vaysse, C.; Couëdelo, L.; Steenhout, P.; Jaeger, J.; Cruz-Hernandez, C.; Ameye, L.; Rigo, J.; Picaud, J.-C.; Saliba, E.; Hays, N.P.; Destaillats, F. Effects on Fatty Acid Metabolism of a New Powdered Human Milk Fortifier Containing Medium-Chain Triacylglycerols and Docosahexaenoic Acid in Preterm Infants. Nutrients 2018, 10, 690.

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