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Nutrients 2018, 10(6), 673; https://doi.org/10.3390/nu10060673

An 8-Week Ketogenic Low Carbohydrate, High Fat Diet Enhanced Exhaustive Exercise Capacity in Mice

1
Graduate School of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan
2
College of Food Science, South China Agricultural University, Guangzhou 510642, China
3
The Key Laboratory of Food Quality and Safety of Guangdong Province, Guangzhou 510642, China
4
Research Organization for Nano and Life Innovation, Waseda University, Tokorozawa 359-1192, Japan
5
Faculty of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan
*
Authors to whom correspondence should be addressed.
Received: 17 April 2018 / Revised: 15 May 2018 / Accepted: 21 May 2018 / Published: 25 May 2018
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Abstract

Current fueling tactics for endurance exercise encourage athletes to ingest a high carbohydrate diet. However, athletes are not generally encouraged to use fat, the largest energy reserve in the human body. A low carbohydrate, high fat ketogenic diet (KD) is a nutritional approach ensuring that the body utilizes lipids. Although KD has been associated with weight-loss, enhanced fat utilization in muscle and other beneficial effects, there is currently no clear proof whether it could lead to performance advantage. To evaluate the effects of KD on endurance exercise capacity, we studied the performance of mice subjected to a running model after consuming KD for eight weeks. Weight dropped dramatically in KD-feeding mice, even though they ate more calories. KD-feeding mice showed enhanced running time without aggravated muscle injury. Blood biochemistry and correlation analysis indicated the potential mechanism is likely to be a keto-adaptation enhanced capacity to transport and metabolize fat. KD also showed a potential preventive effect on organ injury caused by acute exercise, although KD failed to exert protection from muscle injury. Ultimately, KD may contribute to prolonged exercise capacity. View Full-Text
Keywords: ketogenic diet; keto-adaptation; endurance exercise capacity; muscle damage ketogenic diet; keto-adaptation; endurance exercise capacity; muscle damage
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Ma, S.; Huang, Q.; Yada, K.; Liu, C.; Suzuki, K. An 8-Week Ketogenic Low Carbohydrate, High Fat Diet Enhanced Exhaustive Exercise Capacity in Mice. Nutrients 2018, 10, 673.

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