Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants
AbstractHuman milk is recommended for feeding preterm infants. The current pilot study aims to determine whether breast-milk lipidome had any impact on the early growth-pattern of preterm infants fed their own mother’s milk. A prospective-monocentric-observational birth-cohort was established, enrolling 138 preterm infants, who received their own mother’s breast-milk throughout hospital stay. All infants were ranked according to the change in weight Z-score between birth and hospital discharge. Then, we selected infants who experienced “slower” (n = 15, −1.54 ± 0.42 Z-score) or “faster” (n = 11, −0.48 ± 0.19 Z-score) growth; as expected, although groups did not differ regarding gestational age, birth weight Z-score was lower in the “faster-growth” group (0.56 ± 0.72 vs. −1.59 ± 0.96). Liquid chromatography–mass spectrometry lipidomic signatures combined with multivariate analyses made it possible to identify breast-milk lipid species that allowed clear-cut discrimination between groups. Validation of the selected biomarkers was performed using multidimensional statistical, false-discovery-rate and ROC (Receiver Operating Characteristic) tools. Breast-milk associated with faster growth contained more medium-chain saturated fatty acid and sphingomyelin, dihomo-γ-linolenic acid (DGLA)-containing phosphethanolamine, and less oleic acid-containing triglyceride and DGLA-oxylipin. The ability of such biomarkers to predict early-growth was validated in presence of confounding clinical factors but remains to be ascertained in larger cohort studies. View Full-Text
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Alexandre-Gouabau, M.-C.; Moyon, T.; Cariou, V.; Antignac, J.-P.; Qannari, E.M.; Croyal, M.; Soumah, M.; Guitton, Y.; David-Sochard, A.; Billard, H.; Legrand, A.; Boscher, C.; Darmaun, D.; Rozé, J.-C.; Boquien, C.-Y. Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants. Nutrients 2018, 10, 164.
Alexandre-Gouabau M-C, Moyon T, Cariou V, Antignac J-P, Qannari EM, Croyal M, Soumah M, Guitton Y, David-Sochard A, Billard H, Legrand A, Boscher C, Darmaun D, Rozé J-C, Boquien C-Y. Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants. Nutrients. 2018; 10(2):164.Chicago/Turabian Style
Alexandre-Gouabau, Marie-Cécile; Moyon, Thomas; Cariou, Véronique; Antignac, Jean-Philippe; Qannari, El M.; Croyal, Mikaël; Soumah, Mohamed; Guitton, Yann; David-Sochard, Agnès; Billard, Hélène; Legrand, Arnaud; Boscher, Cécile; Darmaun, Dominique; Rozé, Jean-Christophe; Boquien, Clair-Yves. 2018. "Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants." Nutrients 10, no. 2: 164.