Association of Circulating Vitamin E (α- and γ-Tocopherol) Levels with Gallstone Disease
AbstractIn addition to well-established risk factors like older age, female gender, and adiposity, oxidative stress may play a role in the pathophysiology of gallstone disease. Since vitamin E exerts important anti-oxidative functions, we hypothesized that circulating vitamin E levels might be inversely associated with prevalence of gallstone disease. In a cross-sectional study, we measured plasma levels of α- and γ-tocopherol using high performance liquid chromatography in a community-based sample (582 individuals; median age 62 years; 38.5% women). Gallstone disease status was assessed by ultrasound. Multivariable-adjusted logistic regression models were used to estimate the association of circulating α- and γ-tocopherol/cholesterol ratio levels with prevalent gallstone disease. Lower probabilities of having gallstone disease were observed in the top (compared to the bottom) tertile of the plasma α-tocopherol/cholesterol ratio in multivariable-adjusted models (OR (Odds Ratio): 0.31; 95% CI (Confidence Interval): 0.13–0.76). A lower probability of having gallstone disease was also observed for the γ-tocopherol/cholesterol ratio, though the association did not reach statistical significance (OR: 0.77; 95% CI: 0.35–1.69 for 3rd vs 1st tertile). In conclusion, our observations are consistent with the concept that higher vitamin E levels might protect from gallstone disease, a premise that needs to be further addressed in longitudinal studies. View Full-Text
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Waniek, S.; di Giuseppe, R.; Esatbeyoglu, T.; Ratjen, I.; Enderle, J.; Jacobs, G.; Nöthlings, U.; Koch, M.; Schlesinger, S.; Rimbach, G.; Lieb, W. Association of Circulating Vitamin E (α- and γ-Tocopherol) Levels with Gallstone Disease. Nutrients 2018, 10, 133.
Waniek S, di Giuseppe R, Esatbeyoglu T, Ratjen I, Enderle J, Jacobs G, Nöthlings U, Koch M, Schlesinger S, Rimbach G, Lieb W. Association of Circulating Vitamin E (α- and γ-Tocopherol) Levels with Gallstone Disease. Nutrients. 2018; 10(2):133.Chicago/Turabian Style
Waniek, Sabina; di Giuseppe, Romina; Esatbeyoglu, Tuba; Ratjen, Ilka; Enderle, Janna; Jacobs, Gunnar; Nöthlings, Ute; Koch, Manja; Schlesinger, Sabrina; Rimbach, Gerald; Lieb, Wolfgang. 2018. "Association of Circulating Vitamin E (α- and γ-Tocopherol) Levels with Gallstone Disease." Nutrients 10, no. 2: 133.
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