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Nutrients 2018, 10(2), 133; doi:10.3390/nu10020133

Association of Circulating Vitamin E (α- and γ-Tocopherol) Levels with Gallstone Disease

1
Institute of Epidemiology, University of Kiel, 24105 Kiel, Germany
2
Institute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, Germany
3
Biobank PopGen, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
4
Department of Nutrition and Food Science, University of Bonn, 53113 Bonn, Germany
5
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
6
Institute for Biometrics and Epidemiology, German Diabetes Center (DDZ) at Heinrich Heine University Duesseldorf, 40225 Duesseldorf, Germany
*
Author to whom correspondence should be addressed.
Received: 19 December 2017 / Revised: 20 January 2018 / Accepted: 23 January 2018 / Published: 27 January 2018
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Abstract

In addition to well-established risk factors like older age, female gender, and adiposity, oxidative stress may play a role in the pathophysiology of gallstone disease. Since vitamin E exerts important anti-oxidative functions, we hypothesized that circulating vitamin E levels might be inversely associated with prevalence of gallstone disease. In a cross-sectional study, we measured plasma levels of α- and γ-tocopherol using high performance liquid chromatography in a community-based sample (582 individuals; median age 62 years; 38.5% women). Gallstone disease status was assessed by ultrasound. Multivariable-adjusted logistic regression models were used to estimate the association of circulating α- and γ-tocopherol/cholesterol ratio levels with prevalent gallstone disease. Lower probabilities of having gallstone disease were observed in the top (compared to the bottom) tertile of the plasma α-tocopherol/cholesterol ratio in multivariable-adjusted models (OR (Odds Ratio): 0.31; 95% CI (Confidence Interval): 0.13–0.76). A lower probability of having gallstone disease was also observed for the γ-tocopherol/cholesterol ratio, though the association did not reach statistical significance (OR: 0.77; 95% CI: 0.35–1.69 for 3rd vs 1st tertile). In conclusion, our observations are consistent with the concept that higher vitamin E levels might protect from gallstone disease, a premise that needs to be further addressed in longitudinal studies. View Full-Text
Keywords: vitamin E; α- and γ-tocopherol; gallstone disease vitamin E; α- and γ-tocopherol; gallstone disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Waniek, S.; di Giuseppe, R.; Esatbeyoglu, T.; Ratjen, I.; Enderle, J.; Jacobs, G.; Nöthlings, U.; Koch, M.; Schlesinger, S.; Rimbach, G.; Lieb, W. Association of Circulating Vitamin E (α- and γ-Tocopherol) Levels with Gallstone Disease. Nutrients 2018, 10, 133.

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