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Nutrients 2018, 10(2), 122; doi:10.3390/nu10020122

Pre-Meal Effect of Whey Proteins on Metabolic Parameters in Subjects with and without Type 2 Diabetes: A Randomized, Crossover Trial

1
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, DK-8000 Aarhus, Denmark
2
Danish Diabetes Academy, DK-5000 Odense, Denmark
3
NNF Centre for Basic Metabolic Research, University of Copenhagen, DK-2200 Copenhagen, Denmark
4
Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
Received: 26 November 2017 / Revised: 18 January 2018 / Accepted: 22 January 2018 / Published: 25 January 2018
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Abstract

Diabetic dyslipidemia with elevated postprandial triglyceride (TG) responses is characteristic in type 2 diabetes (T2D). Diet and meal timing can modify postprandial lipemia (PPL). The impact of a pre-meal of whey proteins (WP) on lipid metabolism is unidentified. We determined whether a WP pre-meal prior to a fat-rich meal influences TG and apolipoprotein B-48 (ApoB-48) responses differentially in patients with and without T2D. Two matched groups of 12 subjects with and without T2D accomplished an acute, randomized, cross-over trial. A pre-meal of WP (20 g) or water (control) was consumed 15 min before a fat-rich meal (supplemented with 20 g WP in case of water pre-meal). Postprandial responses were examined during a 360-min period. A WP pre-meal significantly increased postprandial concentrations of insulin (P < 0.0001), glucagon (P < 0.0001) and glucose-dependent insulinotropic peptide (GIP) (P < 0.0001) in subjects with and without T2D. We detected no effects of the WP pre-meal on TG, ApoB-48, or non-esterified fatty acids (NEFA) responses to the fat-rich meal in either group. Paracetamol absorption i.e., gastric emptying was delayed by the WP pre-meal (P = 0.039). In conclusion, the WP pre-meal induced similar hormone and lipid responses in subjects with and without T2D. Thus, the WP pre-meal enhanced insulin, glucagon and GIP responses but did not influence lipid or glucose responses. In addition, we demonstrated that a WP pre-meal reduced gastric emptying in both groups. View Full-Text
Keywords: pre-meal; whey proteins; type 2 diabetes; postprandial lipemia pre-meal; whey proteins; type 2 diabetes; postprandial lipemia
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MDPI and ACS Style

Bjørnshave, A.; Hermansen, K.; Holst, J.J. Pre-Meal Effect of Whey Proteins on Metabolic Parameters in Subjects with and without Type 2 Diabetes: A Randomized, Crossover Trial. Nutrients 2018, 10, 122.

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