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Nutrients 2018, 10(1), 31; https://doi.org/10.3390/nu10010031

Concentrations of Plasma Free Palmitoleic and Dihomo-Gamma Linoleic Fatty Acids Are Higher in Children with Abdominal Obesity

1
Grupo de Investigación en Fisiología y Bioquímica (PHYSIS), Universidad de Antioquia, Medellín 050010, Colombia
2
Escuela de Nutrición y Dietética, Universidad de Antioquia, Medellín 050025, Colombia
3
Grupo de Investigación en Determinantes Sociales y Económicos de la Salud y la Nutrición, Universidad de Antioquia, Medellín 050010, Colombia
4
Grupo de Investigación en Demografía y Salud, Universidad de Antioquia, Medellín 050010, Colombia
5
Grupo de Investigación Alimentación y Nutrición Humana, Universidad de Antioquia, Medellín 050010, Colombia
*
Author to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 13 November 2017 / Accepted: 16 November 2017 / Published: 1 January 2018
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Abstract

Increased plasma free fatty acids (FFAs) are associated with cardiometabolic risk factors in adults with abdominal obesity (AO). However, this association remains controversial in children. This study analyzed plasma FFA concentration in children with and without AO. Twenty-nine children classified with AO were matched by age and sex with 29 non-obese individuals. Blood samples were collected after fasting for 10–12 h. Plasma concentration of glucose, insulin, triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were determined by automatized methods. FFAs were analyzed by gas chromatography. Children with and without AO had similar age (7.1 ± 2.6 vs. 7.2 ± 2.7 years; p > 0.05) but obese children showed higher (p < 0.05) body mass index (BMI) (+4.3 kg/m2), systolic blood pressure (+5.1 mmHg), and insulin (+27.8 pmol/L). There were no significant differences in plasma total FFA concentration between groups (1.02 ± 0.61 vs. 0.89 ± 0.37 mmol/L; p > 0.05). However, children with AO had higher palmitoleic acid (0.94 vs. 0.70 wt %; p < 0.05) and dihomo-gamma linoleic acid (DHGL) (2.76 vs. 2.07 wt %; p < 0.05). Palmitoleic and DHGL acids correlated (p < 0.05) with BMI (r = 0.397; r = 0.296, respectively) and with waist circumference (r = 0.380; r = 0.276, respectively). Palmitoleic acid correlated positively with systolic blood pressure (r = 0.386; p < 0.05) and negatively with HDL-C (−0.572; p < 0.01). In summary, children with AO have higher plasmatic concentrations of free palmitoleic and DHGL fatty acids, which correlate with cardiometabolic risk factors. View Full-Text
Keywords: plasma free fatty acids profile; central obesity; waist circumference; cardiometabolic risk factors; gas chromatography plasma free fatty acids profile; central obesity; waist circumference; cardiometabolic risk factors; gas chromatography
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Aristizabal, J.C.; González-Zapata, L.I.; Estrada-Restrepo, A.; Monsalve-Alvarez, J.; Restrepo-Mesa, S.L.; Gaitán, D. Concentrations of Plasma Free Palmitoleic and Dihomo-Gamma Linoleic Fatty Acids Are Higher in Children with Abdominal Obesity. Nutrients 2018, 10, 31.

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