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Nutrients 2009, 1(2), 224-234; doi:10.3390/nu1020224
Article

Bovine Colostrum Supplementation During Running Training Increases Intestinal Permeability

1,2,* , 2,3, 3 and 4
Received: 16 November 2009; Accepted: 30 November 2009 / Published: 2 December 2009
(This article belongs to the Special Issue Sports Nutrition)
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Abstract: Endurance exercise training can increase intestinal permeability which may contribute to the development of gastrointestinal symptoms in some athletes. Bovine colostrum (BC) supplementation reduces intestinal permeability induced by non-steroidal anti-inflammatory drugs. This study aimed to determine whether BC could also reduce intestinal permeability induced by endurance exercise. Thirty healthy adult males (25.0 ± 4.7 yr; mean ± SD) completed eight weeks of running three times per week for 45 minutes at their lactate threshold while consuming 60 g/day of BC, whey protein (WP) or control (CON). Intestinal permeability was assessed at baseline and after eight weeks by measuring the ratio of urinary lactulose (L) and rhamnose (R) excretion. After eight weeks the L/R ratio increased significantly more in volunteers consuming BC (251 ± 140%) compared with WP (21 ± 35%, P < 0.05) and CON (−7 ± 13%, P < 0.02). The increase in intestinal permeability with BC may have been due to BC inducing greater leakiness of tight junctions between enterocytes or by increasing macromolecular transport as it does in neonatal gut. Further research should investigate the potential for BC to increase intestinal macromolecular transport in adults.
Keywords: intestinal transport; exercise; gut permeability; lactulose; rhamnose intestinal transport; exercise; gut permeability; lactulose; rhamnose
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Buckley, J.D.; Butler, R.N.; Southcott, E.; Brinkworth, G.D. Bovine Colostrum Supplementation During Running Training Increases Intestinal Permeability. Nutrients 2009, 1, 224-234.

AMA Style

Buckley JD, Butler RN, Southcott E, Brinkworth GD. Bovine Colostrum Supplementation During Running Training Increases Intestinal Permeability. Nutrients. 2009; 1(2):224-234.

Chicago/Turabian Style

Buckley, Jonathan D.; Butler, Ross N.; Southcott, Emma; Brinkworth, Grant D. 2009. "Bovine Colostrum Supplementation During Running Training Increases Intestinal Permeability." Nutrients 1, no. 2: 224-234.



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