Next Article in Journal
A Tool for Sheep Product Quality: Custom Microarrays from Public Databases
Next Article in Special Issue
Effects of Beta-Alanine on Muscle Carnosine and Exercise Performance: A Review of the Current Literature
Previous Article in Journal
Development and Optimization of a Fluorescent Differential Display PCR System for Analyzing the Stress Response in Lactobacillus sakei Strains
Nutrients 2009, 1(2), 224-234; doi:10.3390/nu1020224
Article

Bovine Colostrum Supplementation During Running Training Increases Intestinal Permeability

1,2,* , 2,3, 3 and 4
1 Nutritional Physiology Research Centre, University of South Australia Adelaide, South Australia, 5000, Australia 2 Sansom Institute for Health Research, University of South Australia Adelaide, South Australia, 5000, Australia 3 Department of Gastroenterology, Adelaide Women’s and Children’s Hospital, Adelaide, South Australia, 5000, Australia 4 Preventative Health National Research Flagship, Commonwealth Scientific and Industrial Research Organisation – Human Nutrition, Adelaide, South Australia, 5000, Australia
* Author to whom correspondence should be addressed.
Received: 16 November 2009 / Accepted: 30 November 2009 / Published: 2 December 2009
(This article belongs to the Special Issue Sports Nutrition)
View Full-Text   |   Download PDF [105 KB, uploaded 2 December 2009]   |   Browse Figure

Abstract

Endurance exercise training can increase intestinal permeability which may contribute to the development of gastrointestinal symptoms in some athletes. Bovine colostrum (BC) supplementation reduces intestinal permeability induced by non-steroidal anti-inflammatory drugs. This study aimed to determine whether BC could also reduce intestinal permeability induced by endurance exercise. Thirty healthy adult males (25.0 ± 4.7 yr; mean ± SD) completed eight weeks of running three times per week for 45 minutes at their lactate threshold while consuming 60 g/day of BC, whey protein (WP) or control (CON). Intestinal permeability was assessed at baseline and after eight weeks by measuring the ratio of urinary lactulose (L) and rhamnose (R) excretion. After eight weeks the L/R ratio increased significantly more in volunteers consuming BC (251 ± 140%) compared with WP (21 ± 35%, P < 0.05) and CON (−7 ± 13%, P < 0.02). The increase in intestinal permeability with BC may have been due to BC inducing greater leakiness of tight junctions between enterocytes or by increasing macromolecular transport as it does in neonatal gut. Further research should investigate the potential for BC to increase intestinal macromolecular transport in adults.
Keywords: intestinal transport; exercise; gut permeability; lactulose; rhamnose intestinal transport; exercise; gut permeability; lactulose; rhamnose
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Buckley, J.D.; Butler, R.N.; Southcott, E.; Brinkworth, G.D. Bovine Colostrum Supplementation During Running Training Increases Intestinal Permeability. Nutrients 2009, 1, 224-234.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert