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Methanetrisulfonic Acid: A Highly Efficient Strongly Acidic Catalyst for Wagner-Meerwein Rearrangement, Friedel-Crafts Alkylation and Acylation Reactions. Examples from Vitamin E Synthesis
Sustainability 2009, 1(2), 209-214; doi:10.3390/su1020209

Selective Reduction of Dimedone

 and *
DSM Nutritional Products Ltd., Research and Development, P.O Box 2676, 4002 Basel, Switzerland
* Author to whom correspondence should be addressed.
Received: 30 March 2009 / Accepted: 13 May 2009 / Published: 14 May 2009
(This article belongs to the Special Issue Green Chemistry for Environment and Health)
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The selective hydrogenation of dimedone (1) to the corresponding monoketone 2 over palladium and Amberlyst 15® is reported. The product is a synthetic building block for the fragrance and pharmaceutical industry. Advantages of the new catalytic procedure are the high catalyst activity and selectivity, less by-product formation, avoidance of the presence of acid, and consequently, less salt formation due to the omission of a neutralization step. Using a substrate/catalyst ratio of >100 compound 2 can be synthesized in 97% yield at full conversion. Recycling of the catalyst several times has been shown to be feasible without any detectable decrease in selectivity.
Keywords: heterogeneous catalysis; ion exchange resins; selective hydrogenation; 1; 3-diketones heterogeneous catalysis; ion exchange resins; selective hydrogenation; 1; 3-diketones
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Létinois, U.; Bonrath, W. Selective Reduction of Dimedone. Sustainability 2009, 1, 209-214.

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