Next Article in Journal
Topical Anti-Nuclear Factor-Kappa B Small Interfering RNA with Functional Peptides Containing Sericin-Based Hydrogel for Atopic Dermatitis
Previous Article in Journal
Potential Use of Biological Proteins for Liver Failure Therapy
Previous Article in Special Issue
Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment
Article Menu

Export Article

Open AccessReview
Pharmaceutics 2015, 7(3), 275-293; doi:10.3390/pharmaceutics7030275

Facilitation of Drug Transport across the Blood–Brain Barrier with Ultrasound and Microbubbles

Department of Neurology, University Medicine Mannheim, Heidelberg University, 68167 Mannheim, Germany
Academic Editor: Gert Fricker
Received: 31 March 2015 / Revised: 13 August 2015 / Accepted: 14 August 2015 / Published: 31 August 2015
(This article belongs to the Special Issue Drug Delivery to Brain)
View Full-Text   |   Download PDF [924 KB, uploaded 31 August 2015]   |  

Abstract

Medical treatment options for central nervous system (CNS) diseases are limited due to the inability of most therapeutic agents to penetrate the blood–brain barrier (BBB). Although a variety of approaches have been investigated to open the BBB for facilitation of drug delivery, none has achieved clinical applicability. Mounting evidence suggests that ultrasound in combination with microbubbles might be useful for delivery of drugs to the brain through transient opening of the BBB. This technique offers a unique non-invasive avenue to deliver a wide range of drugs to the brain and promises to provide treatments for CNS disorders with the advantage of being able to target specific brain regions without unnecessary drug exposure. If this method could be applied for a range of different drugs, new CNS therapeutic strategies could emerge at an accelerated pace that is not currently possible in the field of drug discovery and development. This article reviews both the merits and potential risks of this new approach. It assesses methods used to verify disruption of the BBB with MRI and examines the results of studies aimed at elucidating the mechanisms of opening the BBB with ultrasound and microbubbles. Possible interactions of this novel delivery method with brain disease, as well as safety aspects of BBB disruption with ultrasound and microbubbles are addressed. Initial translational research for treatment of brain tumors and Alzheimer’s disease is presented. View Full-Text
Keywords: blood–brain barrier; focused ultrasound; CNS disease; microbubbles; safety blood–brain barrier; focused ultrasound; CNS disease; microbubbles; safety
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Meairs, S. Facilitation of Drug Transport across the Blood–Brain Barrier with Ultrasound and Microbubbles. Pharmaceutics 2015, 7, 275-293.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top