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Pharmaceutics 2015, 7(3), 175-187; doi:10.3390/pharmaceutics7030175

Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment

The Brain Tumor Center of Excellence, Department of Neurosurgery, Wake Forest University, Medical Center Boulevard, Winston Salem 27157, NC, USA
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Academic Editor: Gert Fricker
Received: 1 April 2015 / Revised: 21 July 2015 / Accepted: 24 July 2015 / Published: 3 August 2015
(This article belongs to the Special Issue Drug Delivery to Brain)
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Abstract

The blood–brain barrier remains a main hurdle to drug delivery to the brain. The prognosis of glioblastoma remains grim despite current multimodal medical management. We review neurosurgical technologies that disrupt the blood–brain barrier (BBB). We will review superselective intra-arterial mannitol infusion, focused ultrasound, laser interstitial thermotherapy, and non-thermal irreversible electroporation (NTIRE). These technologies can lead to transient BBB and blood–brain tumor barrier disruption and allow for the potential of more effective local drug delivery. Animal studies and preliminary clinical trials show promise for achieving this goal. View Full-Text
Keywords: blood–brain barrier; intra-arterial drug delivery; focused ultrasound; laser interstitial thermotherapy; non-thermal irreversible electroporation; glioblastoma blood–brain barrier; intra-arterial drug delivery; focused ultrasound; laser interstitial thermotherapy; non-thermal irreversible electroporation; glioblastoma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rodriguez, A.; Tatter, S.B.; Debinski, W. Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment. Pharmaceutics 2015, 7, 175-187.

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