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Pharmaceutics 2015, 7(3), 255-274; doi:10.3390/pharmaceutics7030255

Potential Use of Biological Proteins for Liver Failure Therapy

1
Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 862-0082, Japan
2
DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 862-0082, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Afzal R. Mohammed
Received: 16 July 2015 / Revised: 17 August 2015 / Accepted: 26 August 2015 / Published: 31 August 2015
View Full-Text   |   Download PDF [1592 KB, uploaded 31 August 2015]   |  

Abstract

Biological proteins have unlimited potential for use as pharmaceutical products due to their various biological activities, which include non-toxicity, biocompatibility, and biodegradability. Recent scientific advances allow for the development of novel innovative protein-based products that draw on the quality of their innate biological activities. Some of them hold promising potential for novel therapeutic agents/devices for addressing hepatic diseases such as hepatitis, fibrosis, and hepatocarcinomas. This review attempts to provide an overview of the development of protein-based products that take advantage of their biological activity for medication, and discusses possibilities for the therapeutic potential of protein-based products produced through different approaches to specifically target the liver (or hepatic cells: hepatocytes, hepatic stellate cells, liver sinusoidal endothelial cells, and Kupffer cells) in the treatment of hepatic diseases. View Full-Text
Keywords: albumin; lactoferrin; erythropoietin; α1-acid glycoprotein; gelatin; hemoglobin; nanomedicine; drug delivery albumin; lactoferrin; erythropoietin; α1-acid glycoprotein; gelatin; hemoglobin; nanomedicine; drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Taguchi, K.; Yamasaki, K.; Seo, H.; Otagiri, M. Potential Use of Biological Proteins for Liver Failure Therapy. Pharmaceutics 2015, 7, 255-274.

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