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Pharmaceutics 2013, 5(4), 609-620; doi:10.3390/pharmaceutics5040609
Article

Preparation of Microcapsules Containing β-Carotene with Thermo Sensitive Curdlan by Utilizing Reverse Dispersion

1
, 2
 and 1,*
Received: 26 September 2013; in revised form: 30 October 2013 / Accepted: 12 November 2013 / Published: 21 November 2013
(This article belongs to the Special Issue Microencapsulation Technology Applied to Pharmaceutics 2014)
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Abstract: We have tried to microencapsulate β-carotene with curdlan of a thermogelation type polysaccharide. Microcapsules were prepared by utilizing reverse dispersion, in which salada oil was the continuous phase (O’) and the curdlan water slurry (W) was the dispersed phase. β-carotene (O) as a core material was broken into fine oil droplets in the dispersed phase to form the (O/W) dispersion. The (O/W) dispersion was poured in the continuous phase (O’) and stirred to form the (O/W)/O’ dispersion at room temperature and then, temperature of the dispersion was raised to 80 °C to prepare curdlan-microcapusles containing β-carotene. In this microencapsulation process, the concentrations of curdlan and oil soluble surfactant and the impeller speed to form the (O/W)/O’ dispersion were mainly changed stepwise. We were able to prepare microcapsules by the microencapsulation method adopted here. The content of core material was increased with the curdlan concentration and decreased with the impeller speed and the oil soluble surfactant concentration. With the curdlan concentration, the drying rate of microcapsules was decreased and the retention ability for water was increased due to the stable preservation of β-carotene.
Keywords: curdlan microcapsule; reverse dispersion; thermogelation; β-carotene; liquid liquid dispersion curdlan microcapsule; reverse dispersion; thermogelation; β-carotene; liquid liquid dispersion
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Taguchi, Y.; Ono, F.; Tanaka, M. Preparation of Microcapsules Containing β-Carotene with Thermo Sensitive Curdlan by Utilizing Reverse Dispersion. Pharmaceutics 2013, 5, 609-620.

AMA Style

Taguchi Y, Ono F, Tanaka M. Preparation of Microcapsules Containing β-Carotene with Thermo Sensitive Curdlan by Utilizing Reverse Dispersion. Pharmaceutics. 2013; 5(4):609-620.

Chicago/Turabian Style

Taguchi, Yoshinari; Ono, Fumiyasu; Tanaka, Masato. 2013. "Preparation of Microcapsules Containing β-Carotene with Thermo Sensitive Curdlan by Utilizing Reverse Dispersion." Pharmaceutics 5, no. 4: 609-620.


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