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Pectosomes and Chitosomes as Delivery Systems for Metronidazole: The One-Pot Preparation Method
Drug Transport and Delivery Research Group, Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, Tromsø 9037, Norway
Department of Pharmaceutics, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb 10000, Croatia
Department of Clinical Pharmacology, Umeå University, Umeå SE-90185, Sweden
* Author to whom correspondence should be addressed.
Received: 16 August 2013; in revised form: 29 August 2013 / Accepted: 4 September 2013 / Published: 6 September 2013
Abstract: Mucoadhesive liposomes offer a potential for improved residence time of liposomal systems targeting contact with mucosal tissues, such as in buccal, oral, colon, and vaginal drug delivery. Most of the currently available methods rely on the coating of preformed liposomes by various mucoadhesive polymers. The aim of this study was to develop novel mucoadhesive system by the one-pot preparation method. The pectin- and chitosan-containing liposomes, namely pectosomes and chitosomes, were prepared by the modified solvent injection method. In order to optimize this novel delivery system, we used pectins and chitosans of both high and low degree of esterification/deacetylation (DE/DD), respectively. Sonication was applied to reduce the original vesicle size. All vesicles were characterized for their size, zeta potential, metronidazole entrapment, and stability. Both pectosomes and chitosomes were found to entrap more metronidazole than conventional plain liposomes. Preliminary data indicate that the polymer is present on the liposomal surface, embedded within inner liposomal bilayers, and entrapped inside the aqueous compartment. The next step in the evaluation of this system is the testing of its mucoadhesiveness.
Keywords: liposomes; pectosomes; chitosomes; metronidazole; mucoadhesion; polymer-coating; vaginal therapy
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Andersen, T.; Vanić, Ž.; Flaten, G.E.; Mattsson, S.; Tho, I.; Škalko-Basnet, N. Pectosomes and Chitosomes as Delivery Systems for Metronidazole: The One-Pot Preparation Method. Pharmaceutics 2013, 5, 445-456.
Andersen T, Vanić Ž, Flaten GE, Mattsson S, Tho I, Škalko-Basnet N. Pectosomes and Chitosomes as Delivery Systems for Metronidazole: The One-Pot Preparation Method. Pharmaceutics. 2013; 5(3):445-456.
Andersen, Toril; Vanić, Željka; Flaten, Gøril E.; Mattsson, Sofia; Tho, Ingunn; Škalko-Basnet, Nataša. 2013. "Pectosomes and Chitosomes as Delivery Systems for Metronidazole: The One-Pot Preparation Method." Pharmaceutics 5, no. 3: 445-456.