Pharmaceutics 2013, 5(3), 457-471; doi:10.3390/pharmaceutics5030457
Review

Bioavailability of Polyphenol Liposomes: A Challenge Ahead

Received: 1 August 2013; in revised form: 29 August 2013 / Accepted: 4 September 2013 / Published: 17 September 2013
(This article belongs to the Special Issue Liposome Technologies)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Dietary polyphenols, including flavonoids, have long been recognized as a source of important molecules involved in the prevention of several diseases, including cancer. However, because of their poor bioavailability, polyphenols remain difficult to be employed clinically. Over the past few years, a renewed interest has been devoted to the use of liposomes as carriers aimed at increasing the bioavailability and, hence, the therapeutic benefits of polyphenols. In this paper, we review the causes of the poor bioavailability of polyphenols and concentrate on their liposomal formulations, which offer a means of improving their pharmacokinetics and pharmacodynamics. The problems linked to their development and their potential therapeutic advantages are reviewed. Future directions for liposomal polyphenol development are suggested.
Keywords: polyphenols; flavonoids; liposomes; lipid polyphenol interaction; bioavailability
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MDPI and ACS Style

Mignet, N.; Seguin, J.; Chabot, G.G. Bioavailability of Polyphenol Liposomes: A Challenge Ahead. Pharmaceutics 2013, 5, 457-471.

AMA Style

Mignet N, Seguin J, Chabot GG. Bioavailability of Polyphenol Liposomes: A Challenge Ahead. Pharmaceutics. 2013; 5(3):457-471.

Chicago/Turabian Style

Mignet, Nathalie; Seguin, Johanne; Chabot, Guy G. 2013. "Bioavailability of Polyphenol Liposomes: A Challenge Ahead." Pharmaceutics 5, no. 3: 457-471.

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