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Pharmaceutics 2012, 4(4), 563-589; doi:10.3390/pharmaceutics4040563
Review

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in Preclinical Studies of Antivascular Treatments

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Received: 29 June 2012; in revised form: 29 October 2012 / Accepted: 30 October 2012 / Published: 7 November 2012
(This article belongs to the Special Issue DCE-MRI in Preclinical Imaging)
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Abstract: Antivascular treatments can either be antiangiogenic or targeting established tumour vasculature. These treatments affect the tumour microvasculature and microenvironment but may not change clinical measures like tumour volume and growth. In research on antivascular treatments, information on the tumour vasculature is therefore essential. Preclinical research is often used for optimization of antivascular drugs alone or in combined treatments. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an in vivo imaging method providing vascular information, which has become an important tool in both preclinical and clinical research. This review discusses common DCE-MRI imaging protocols and analysis methods and provides an overview of preclinical research on antivascular treatments utilizing DCE-MRI.
Keywords: DCE-MRI; angiogenesis inhibitors; vascular disrupting agents; preclinical studies DCE-MRI; angiogenesis inhibitors; vascular disrupting agents; preclinical studies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nielsen, T.; Wittenborn, T.; Horsman, M.R. Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in Preclinical Studies of Antivascular Treatments. Pharmaceutics 2012, 4, 563-589.

AMA Style

Nielsen T, Wittenborn T, Horsman MR. Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in Preclinical Studies of Antivascular Treatments. Pharmaceutics. 2012; 4(4):563-589.

Chicago/Turabian Style

Nielsen, Thomas; Wittenborn, Thomas; Horsman, Michael R. 2012. "Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in Preclinical Studies of Antivascular Treatments." Pharmaceutics 4, no. 4: 563-589.



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