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Pharmaceutics 2012, 4(4), 563-589; doi:10.3390/pharmaceutics4040563

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in Preclinical Studies of Antivascular Treatments

Department of Experimental Clinical Oncology, Aarhus University Hospital, DK-8000 Aarhus C, Denmark
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Author to whom correspondence should be addressed.
Received: 29 June 2012 / Revised: 29 October 2012 / Accepted: 30 October 2012 / Published: 7 November 2012
(This article belongs to the Special Issue DCE-MRI in Preclinical Imaging)
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Abstract

Antivascular treatments can either be antiangiogenic or targeting established tumour vasculature. These treatments affect the tumour microvasculature and microenvironment but may not change clinical measures like tumour volume and growth. In research on antivascular treatments, information on the tumour vasculature is therefore essential. Preclinical research is often used for optimization of antivascular drugs alone or in combined treatments. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an in vivo imaging method providing vascular information, which has become an important tool in both preclinical and clinical research. This review discusses common DCE-MRI imaging protocols and analysis methods and provides an overview of preclinical research on antivascular treatments utilizing DCE-MRI.
Keywords: DCE-MRI; angiogenesis inhibitors; vascular disrupting agents; preclinical studies DCE-MRI; angiogenesis inhibitors; vascular disrupting agents; preclinical studies
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Nielsen, T.; Wittenborn, T.; Horsman, M.R. Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in Preclinical Studies of Antivascular Treatments. Pharmaceutics 2012, 4, 563-589.

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