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• Whisenant, J
• Loveless, M
• Yankeelov, T
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• Whisenant, J
• Loveless, M
• Yankeelov, T
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• Whisenant, J
• Loveless, M
• Yankeelov, T

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Pharmaceutics 2012, 4(3), 442-478; doi:10.3390/pharmaceutics4030442

Dissertation

Practical Dynamic Contrast Enhanced MRI in Small Animal Models of Cancer: Data Acquisition, Data Analysis, and Interpretation

Stephanie L. Barnes ^1,2 , Jennifer G. Whisenant ^1,3 , Mary E. Loveless ¹  and Thomas E. Yankeelov ^{1,2,3,4,5,6,7,}*

¹ Institute of Imaging Science, Vanderbilt University, Nashville, TN, 37232-2310, USA ² Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232, USA ³ Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN 37232, USA ⁴ Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235-1826, USA ⁵ Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235, USA ⁶ Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232-6838, USA ⁷ Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA

* Author to whom correspondence should be addressed.

Received: 20 July 2012; in revised form: 1 September 2012 / Accepted: 10 September 2012 / Published: 19 September 2012

(This article belongs to the Special Issue DCE-MRI in Preclinical Imaging)

Download PDF Full-Text [537 KB, uploaded 19 September 2012 16:51 CEST]

Abstract: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) consists of the continuous acquisition of images before, during, and after the injection of a contrast agent. DCE-MRI allows for noninvasive evaluation of tumor parameters related to vascular perfusion and permeability and tissue volume fractions, and is frequently employed in both preclinical and clinical investigations. However, the experimental and analytical subtleties of the technique are not frequently discussed in the literature, nor are its relationships to other commonly used quantitative imaging techniques. This review aims to provide practical information on the development, implementation, and validation of a DCE-MRI study in the context of a preclinical study (though we do frequently refer to clinical studies that are related to these topics).

Keywords: DCE-MRI; mouse; cancer; diffusion; FLT; FDG; FMISO

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