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Pharmaceutics 2012, 4(3), 430-441; doi:10.3390/pharmaceutics4030430

Influence of the Efavirenz Micronization on Tableting and Dissolution

1,* , 1
2 Laboratory of Antibiotics, Biochemistry, Institute of Biology, Universidade Federal Fluminense, Campus of Valonguinho, Niterói, RJ, CEP: 24.210-130, Brazil 3 Institute of Drug Technology, Fundação Oswaldo Cruz, Av. Comandante Guaranys, 447, Curicica, Rio de Janeiro, RJ, CEP: 22.775-903, Brazil
* Author to whom correspondence should be addressed.
Received: 8 August 2012 / Revised: 2 September 2012 / Accepted: 2 September 2012 / Published: 12 September 2012
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The purpose of this study was to propose an analytical procedure that provides the effects of particle size and surface area on dissolution of efavirenz. Five different batches obtained by different micronization processes and with different particle size distribution and surface area were studied. The preformulation studies and dissolution curves were used to confirm the particle size distribution effect on drug solubility. No polymorphic variety or amorphization was observed in the tested batches and the particle size distribution was determined as directly responsible for the improvement of drug dissolution. The influence of the preparation process on the tablets derived from efavirenz was observed in the final dissolution result in which agglomeration, usually seen in non-lipophilic micronized material, was avoided through the use of an appropriate wet granulation method. For these reasons, micronization may represent one viable alternative for the formulation of brick dust drugs.
Keywords: AIDS; size distribution; surface area; bioavailability; brick dust drug AIDS; size distribution; surface area; bioavailability; brick dust drug
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pinto, E.C.; Carmo, F.A.; Honório, T.S.; Barros, R.C.S.A.; Castro, H.C.R.; Rodrigues, C.R.; Esteves, V.S.D.; Rocha, H.V.A.; Sousa, V.P.; Cabral, L.M. Influence of the Efavirenz Micronization on Tableting and Dissolution. Pharmaceutics 2012, 4, 430-441.

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